4-溴-7-甲氧基-1-茚酮合成路线 （共 15 条）
反应条件
1: 97 percent / 180 °C
2: 14 percent / Polyphosphorsaeure / 12 h / 80 °C
3: 1) LDA / 1) THF, hexane, 10 min 2) r.t., 12 h
View Scheme
参考文献
Pudleiner, Heinz; Laatsch, Hartmut
Liebigs Annalen der Chemie, 1990 , # 5 p. 423 - 432
反应条件
1: 96 percent / 5percent aq.NaOH / 4 h / 80 °C
2: 97 percent / 180 °C
3: 14 percent / Polyphosphorsaeure / 12 h / 80 °C
4: 1) LDA / 1) THF, hexane, 10 min 2) r.t., 12 h
View Scheme
参考文献
Pudleiner, Heinz; Laatsch, Hartmut
Liebigs Annalen der Chemie, 1990 , # 5 p. 423 - 432
反应条件
lithium diisopropyl amide
1) THF, hexane, 10 min 2) r.t., 12 h; Multistep reaction;
参考文献
Pudleiner, Heinz; Laatsch, Hartmut
Liebigs Annalen der Chemie, 1990 , # 5 p. 423 - 432
参考文献
Pudleiner, Heinz; Laatsch, Hartmut
Liebigs Annalen der Chemie, 1990 , # 5 p. 423 - 432
反应条件
1: sodium acetate; hydrogen; palladium 10 on activated carbon / ethanol / 3040.2 Torr
2: hydrogenchloride; sodium azide / water / 0 - 20 °C
View Scheme
参考文献
Abate, Carmen; Selivanova, Svetlana V.; Mueller, Adrienne; Kraemer, Stefanie D.; Schibli, Roger; Marottoli, Roberta; Perrone, Roberto; Berardi, Francesco; Niso, Mauro; Ametamey, Simon M.
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 920 - 930
