乙基beta-乙氧羰基-gamma-氧代-3-吡啶丁酸酯合成路线 （共 5 条）
反应条件
sulfuric acid; water 3 h; Heating / reflux;
参考文献
Bourguignon, Jean-Jacques; Maitre, Michel; Klotz, Evelyne; Schmitt, Martine; Gobaille, Serge; Macher, Jean-Paul
Patent: US2005/113366 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
phosphate buffer T=25°C; pH=6.5; 240 h;
参考文献
Forzato, Cristina; Furlan, Giada; Nitti, Patrizia; Pitacco, Giuliana; Valentin, Ennio; Zangrando, Ennio; Buzzini, Pietro; Goretti, Marta; Turchetti, Benedetta
Tetrahedron Asymmetry, 2008 , vol. 19, # 17 p. 2026 - 2036
反应条件
1: aqueous HCl 2: ethanolic HCl View Scheme
参考文献
Forzato, Cristina; Furlan, Giada; Nitti, Patrizia; Pitacco, Giuliana; Valentin, Ennio; Zangrando, Ennio; Buzzini, Pietro; Goretti, Marta; Turchetti, Benedetta
Tetrahedron Asymmetry, 2008 , vol. 19, # 17 p. 2026 - 2036
反应条件
sodium hydride in diethyl ether
T=20°C; 48 h;
参考文献
Bourguignon, Jean-Jacques; Maitre, Michel; Klotz, Evelyne; Schmitt, Martine; Gobaille, Serge; Macher, Jean-Paul
Patent: US2005/113366 A1, 2005 ;
Location in patent: Page/Page column 7-8 ;
反应条件
ethanol; potassium ethanolate
参考文献
Sugasawa et al.
Pharmaceutical Bulletin, 1954 , vol. 2, p. 39
