2-(1,1-二甲基乙基)-1H-吡咯合成路线 （共 15 条）
反应条件
oxygen; rose bengal in methanol
参考文献
Lightner,D.A.; Pak,C.-S.
Journal of Organic Chemistry, 1975 , vol. 40, p. 2724 - 2728
反应条件
potassium hydroxide in dimethyl sulfoxide; pentane
T=70°C; Addition; Cyclisation; Rearrangement; P=12160 Torr; 0.1 h;
参考文献
Trofimov, Boris A.; Al'bina, Mikhaleva I.; Vasil'tsov, Alexander M.; Schmidt, Elena Yu.; Tarasova, Ol'ga A.; Morozova, Ludmila V.; Sobenina, Lubov' N.; Preiss, Thomas; Henkelmann, Jochem
Synthesis, 2000 , # 8 p. 1125 - 1132
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-30 - 0°C; 2.5 h;
2: With acetic acid in tetrahydrofuran; hexane
参考文献
Tanguy, Chloe; Bertus, Philippe; Szymoniak, Jan; Larionov, Oleg V.; De Meijere, Armin
Synlett, 2006 , # 14 p. 2339 - 2341
反应条件
potassium hydroxide in dimethyl sulfoxide
T=100°C; 3 h;
参考文献
Tarasova, O. A.; Korostova, S. E.; Mikhaleva, A. I.; Sobenina, L. N.; Nesterenko, R. N.; et al.
Russian Journal of Organic Chemistry, 1994 , vol. 30, # 6.1 p. 863 - 869
Zhurnal Organicheskoi Khimii, 1994 , vol. 30, # 6 p. 810 - 815
反应条件
potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide
T=0°C; 0.5 h;
参考文献
Spaggiari, Alberto; Vaccari, Daniele; Davoli, Paolo; Prati, Fabio
Synthesis, 2006 , # 6 p. 995 - 998
反应条件
ethylene glycol; potassium hydroxide
6 h; RefluxInert atmosphere;
参考文献
Harman, W. Hill; Harris, T. David; Freedman, Danna E.; Fong, Henry; Chang, Alicia; Rinehart, Jeffrey D.; Ozarowski, Andrew; Sougrati, Moulay T.; Grandjean, Fernande; Long, Gary J.; Long, Jeffrey R.; Chang, Christopher J.
Journal of the American Chemical Society, 2010 , vol. 132, # 51 p. 18115 - 18126
反应条件
HBF4*(CH3)2O in xylene
0.25 h; Heating;
参考文献
Wasserman, Harry H.; Dion, Robert P.; Fukuyama, James M.
Heterocycles, 1989 , vol. 28, # 2 p. 629 - 631
反应条件
1: Et3N / CH2Cl2 / Heating
2: (PhO)3P-Cl2; Et3N / toluene / 3 h / -25 °C
3: potassium tert-butoxide / tetrahydrofuran; dimethylformamide / 0.5 h / 0 °C
View Scheme
参考文献
Spaggiari, Alberto; Vaccari, Daniele; Davoli, Paolo; Prati, Fabio
Synthesis, 2006 , # 6 p. 995 - 998
反应条件
1: ammonium chloride; zinc / tetrahydrofuran; water / 0 °C
2: Jone's reagent / diethyl ether / 0 - 20 °C
3: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 20 °C
4: triethylamine / dichloromethane / 0 °C
5: copper(I) bromide / toluene / 120 °C / |Inert atmosphere
View Scheme
参考文献
Du, Wei; Zhao, Mi-Na; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui
Chemical Communications, 2014 , vol. 50, # 56 p. 7437 - 7439
反应条件
1: Jone's reagent / diethyl ether / 0 - 20 °C
2: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 20 °C
3: triethylamine / dichloromethane / 0 °C
4: copper(I) bromide / toluene / 120 °C / |Inert atmosphere
View Scheme
参考文献
Du, Wei; Zhao, Mi-Na; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui
Chemical Communications, 2014 , vol. 50, # 56 p. 7437 - 7439
