2-氨基噻唑-4-甲酸乙酯合成路线 （共 34 条）
反应条件
in ethanol T=105°C; 1.5 h; Inert atmosphere;
参考文献
Ehmke, Veronika; Quinsaat, Jose Enrico Q.; Rivera-Fuentes, Pablo; Heindl, Cornelia; Freymond, Celine; Rottmann, Matthias; Brun, Reto; Schirmeister, Tanja; Diederich, Francois
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 30 p. 5764 - 5768
反应条件
1: EtOCHCHCO2Et With N-bromosuccinmide in 1,4-dioxane; water T=-10 - 20°C; 1 h; 2: thiourea in 1,4-dioxane; water T=80°C; 1 h; 3: With ammonia in 1,4-dioxane; water T=20°C; 0.166667 h;
参考文献
HANGZHOU BENSHENG PHARACEUTICALS CO., LTD.; Xu, Rongzhen; Xie, Fuwen; Lai, Hongxi; Rong, Frank
Patent: US2013/178470 A1, 2013 ;
Location in patent: Paragraph 0104; 0105 ;
反应条件
thiourea in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol
反应条件
1: in acetonitrile T=20°C; Hantzsch reaction; 2: With methanol; ammonia in dichloromethane
参考文献
Tetrahedron Letters, , vol. 43, # 39 p. 7051 - 7053
反应条件
water Erwaermen des Reaktionsprodukts mit aethanol. H2SO4;
参考文献
Journal of the American Chemical Society, , vol. 68, p. 268
反应条件
1: CS2; bromine 2: Zerlegen des entstandenen Hydrobromids mit Ammoniak View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 261, p. 26
反应条件
lithium aluminium tetrahydride
参考文献
IRM LLC; CHE, Jianwei; DING, Qiang; HE, Xiaohui; LIU, Hong; LIU, Yahua; MICHELLYS, Pierre-Yves; OKRAM, Barun; WU, Xu; YANG, Kunyong; ZHU, Xuefeng
Patent: WO2011/14795 A2, 2011 ;
Location in patent: Page/Page column 92 ;
WO 2011/014795 A2
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite in water T=20°C; 2.16667 h; Cooling with salt-ice;
参考文献
PHARMAGENE LABORATORIES LIMITED
Patent: WO2005/80367 A1, 2005 ;
Location in patent: Page/Page column 109 ;
反应条件
1: N-chlorosuccinimide / acetonitrile / 20 °C 2: 30 g / isoamylnitrite; CuBr2 / acetonitrile / 2 h / 0 °C View Scheme
参考文献
Hodgetts, Kevin J.; Kershaw, Mark T.
Organic Letters, 2002 , vol. 4, # 8 p. 1363 - 1365
反应条件
1: With water; sodium hydroxide T=20°C; 5 h; 2: With hydrogenchloride in water pH=1;
参考文献
Mitsui Chemicals Agro, Inc.
Patent: EP2325165 A1, 2011 ;
Location in patent: Page/Page column 460 ;
