2-[(4-甲基苯基)甲基]苯甲酸合成路线 （共 14 条）
反应条件
chromium(VI) oxide; trifluoroacetic anhydride 1.) CH2Cl2, 0 deg C to rt, 2.) aq. AcOH, rt, 3 h; Yield given. Multistep reaction;
参考文献
Almeida, Wanda P.; Costa, Paulo R.R.
Synthetic Communications, 1996 , vol. 26, # 23 p. 4507 - 4518
反应条件
ammonium hydroxide; water; zinc
参考文献
Gresly
Justus Liebigs Annalen der Chemie, 1886 , vol. 234, p. 238
反应条件
n-butyllithium in tetrahydrofuran
-78 deg C, 70 min, -78 deg C to rt;
参考文献
Almeida, Wanda P.; Costa, Paulo R.R.
Synthetic Communications, 1996 , vol. 26, # 23 p. 4507 - 4518
反应条件
chloro-trimethyl-silane; sodium iodide in acetonitrile
2 h; Heating;
参考文献
Sabitha, Gowravaram; Yadav
Synthetic Communications, 1998 , vol. 28, # 16 p. 3065 - 3071
反应条件
1: AlCl3 / nitrobenzene / 20 °C
2: Zn; HgCl2; conc. HCl / H2O; toluene / 40 h / 20 °C
View Scheme
参考文献
Mahmoodi; Salehpour
Russian Journal of Organic Chemistry, 2003 , vol. 39, # 12 p. 1760 - 1763
反应条件
1: AlCl3 / nitrobenzene / 20 °C
2: Zn; HgCl2; conc. HCl / H2O; toluene / 40 h / 20 °C
View Scheme
参考文献
Mahmoodi; Salehpour
Russian Journal of Organic Chemistry, 2003 , vol. 39, # 12 p. 1760 - 1763
反应条件
1: 88 percent / nBuLi / tetrahydrofuran / -85 deg C to rt
2: 88 percent / NaBH4 / trifluoroacetic acid / 10 deg C to 15 deg C, rt, overnight
3: 75 percent / nBuLi / tetrahydrofuran / -78 deg C, 70 min, -78 deg C to rt
View Scheme
参考文献
Almeida, Wanda P.; Costa, Paulo R.R.
Synthetic Communications, 1996 , vol. 26, # 23 p. 4507 - 4518
反应条件
1: 88 percent / nBuLi / tetrahydrofuran / -85 deg C to rt
2: 88 percent / NaBH4 / trifluoroacetic acid / 10 deg C to 15 deg C, rt, overnight
3: 75 percent / nBuLi / tetrahydrofuran / -78 deg C, 70 min, -78 deg C to rt
View Scheme
参考文献
Almeida, Wanda P.; Costa, Paulo R.R.
Synthetic Communications, 1996 , vol. 26, # 23 p. 4507 - 4518
反应条件
magnesium
anschliessend Behandeln mit CO2;
参考文献
Catch; Evans
Journal of the Chemical Society, 1957 , p. 2787
反应条件
1: diethyl ether / Erhitzen des Reaktionsprodukts mit rotem Phosphor und Jod in Essigsaeure
2: magnesium / anschliessend Behandeln mit CO2
View Scheme
参考文献
Catch; Evans
Journal of the Chemical Society, 1957 , p. 2787
