4-甲基-2,3-二氨基吡啶合成路线 （共 9 条）
反应条件
hydrogen; 5 Pd(II)/C(eggshell) in methanol T=20°C; P=760.051 Torr; 2 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.; DISCH, Jeremy, S.
Patent: WO2010/88574 A1, 2010 ;
Location in patent: Page/Page column 123 ;
WO 2010/088574 A1
反应条件
hydrogen; Raney nickel, RaNi in methanol P=2585.81 Torr; 14 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/84303 A1, 2008 ;
Location in patent: Page/Page column 53 ;
WO 2008/084303 A1
反应条件
1: CH2Cl2 / Heating 2: conc. HCl View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 10, # 17 p. 1975 - 1978
反应条件
1: polyphosphoric acid / 80 - 90 °C 2: 1.) NaH / 1.) DMF, 25 deg C, 20 min 3: HCOOH / 12 h / 25 °C View Scheme
参考文献
Mantlo, Nathan B.; Chakravarty, Prasun K.; Ondeyka, Debra L.; Siegl, Peter K. S.; Chang, Raymond S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2919 - 2922
反应条件
1: With toluene-4-sulfonic acid T=125°C; 10 h; 2: With hydrogenchloride in water 1 h; Heating / reflux; 3: in water pH=7;
参考文献
UCB S.A.
Patent: WO2006/128692 A2, 2006 ;
Location in patent: Page/Page column 132; 133 ;
反应条件
1: 52 percent / 3 h / 140 - 150 °C 2: 70 percent / KMnO4, Na2CO3 / H2O / 2 h / Heating 3: Heating View Scheme
参考文献
Bukowski; Janowiec
Pharmazie, 1988 , vol. 43, # 5 p. 315 - 317
反应条件
1: T=100°C; 3 h; 2: With ammonia; sodium carbonate in water pH=9; 1 h;
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: EP1724271 A1, 2006 ;
Location in patent: Page/Page column 58 ;
EP 1724271 A1
反应条件
1: 80 percent / 5 h / Heating 2: 85 percent / H2O / 0.25 h / Heating View Scheme
参考文献
Bukowski; Janowiec
Pharmazie, 1988 , vol. 43, # 5 p. 315 - 317
反应条件
1: With trichlorophosphate
T=170 - 180°C; 4 h; Heating / reflux;
2: With sodium hydroxide in water
参考文献
CRYSTALGENOMICS, INC.
Patent: WO2007/83978 A1, 2007 ;
Location in patent: Page/Page column 104 ;
WO 2007/083978 A1
