4'-甲基-3-硝基联苯合成路线 （共 38 条）
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium carbonate in neat (no solvent)
T=110°C; Suzuki-Miyaura Coupling; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
PEG 4000; palladium diacetate; potassium carbonate
T=120°C; 12 h;
参考文献
Wang, Liang; Zhang, Yuhong; Liu, Leifang; Wang, Yanguang
Journal of Organic Chemistry, 2006 , vol. 71, # 3 p. 1284 - 1287
反应条件
tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; palladium diacetate in xylene
T=130°C; 70 h;
参考文献
Hassan, Jwanro; Hathroubi, Chokri; Gozzi, Christel; Lemaire, Marc
Tetrahedron, 2001 , vol. 57, # 37 p. 7845 - 7855
反应条件
tetra-butylammonium acetate; Pd EnCat-30TM in ethanol
T=140°C; Suzuki cross-coupling; 0.166667 h; microwave irradiation;
参考文献
Baxendale, Ian R.; Griffiths-Jones, Charlotte M.; Ley, Steven V.; Tranmer, Geoffrey K.
Chemistry - A European Journal, 2006 , vol. 12, # 16 p. 4407 - 4416
反应条件
copper(I) oxide; bis(acetylacetonato) palladium; 1,10-phenanthroline; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1-methyl-pyrrolidin-2-one
T=50 - 190°C; 0.166667 h; Inert atmosphereMicrowave irradiation;
参考文献
Goossen, Luksa J.; Rodriguez, Nuria; Lange, Paul P.; Linder, Christophe
Angewandte Chemie - International Edition, 2010 , vol. 49, # 6 p. 1111 - 1114
反应条件
C49H74N4O34Pd(2+)*2C2H3O2(1-); sodium carbonate in water
Suzuki-Miyaura Coupling; 24 h; Sealed tubeRefluxGreen chemistry; Catalytic behavior;
参考文献
Zhang, Guofu; Luan, Yuxin; Han, Xingwang; Wang, Yong; Wen, Xin; Ding, Chengrong; Gao, Jianrong
Green Chemistry, 2013 , vol. 15, # 8 p. 2081 - 2085
反应条件
sodium hydroxide; Na2[PdCl4]; sodium lauryl sulfate
T=100°C; Hiyama cross-coupling; 0.1 h;
参考文献
Ranu, Brindaban C.; Dey, Raju; Chattopadhyay, Kalicharan
Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3430 - 3432
反应条件
tris-(dibenzylideneacetone)dipalladium(0); copper(I) bromide dimethylsulfide complex; trifuran-2-yl-phosphane in tetrahydrofuran
Stille coupling; Heating;
参考文献
Dubbaka, Srinivas Reddy; Vogel, Pierre
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15292 - 15293
反应条件
1: caesium carbonate / isopropyl alcohol / 24 h / 50 °C
2: bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 12 h / 20 °C
View Scheme
参考文献
Pena-Lopez, Miguel; Sarandeses, Luis A.; Perez Sestelo, Jose
European Journal of Organic Chemistry, 2013 , # 13 p. 2545 - 2554
反应条件
trifluoroacetic acid
T=65 - 70°C; 3 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Patrick, Timothy B.; Willaredt, Richard P.; DeGonia, David J.
Journal of Organic Chemistry, 1985 , vol. 50, # 13 p. 2232 - 2235
