hydrogenchloride; sodium hydroxide; tetrabutyl-ammonium chloride in tetrahydrofuran; toluene

potassium hydride in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide 48 h; Ambient temperature;

in tetrahydrofuran

1: 80 percent / tetrahydrofuran / 0.17 h / 0 °C / 3 recycles 2: 30 percent / Potassium hydride / hexamethylphosphoric acid triamide; tetrahydrofuran / 48 h / Ambient temperature View Scheme