N-甲酰基-DL-亮氨酸合成路线 （共 16 条）
反应条件
E. coli BL21 Star (DE3) S30 extract in aq. buffer T=37°C; pH=7.5; 6 h;
参考文献
Fischer,E.; Warburg
Chemische Berichte, 1905 , vol. 38, p. 3999
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=0 - 20°C; Mitsunobu reaction; Inert atmosphere;
参考文献
Venukadasula, Phanindra K. M.; Chegondi, Rambabu; Maitra, Soma; Hanson, Paul R.
Organic Letters, 2010 , vol. 12, # 7 p. 1556 - 1559
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; 24 h;
参考文献
Kumaraswamy; Markondaiah
Tetrahedron Letters, 2008 , vol. 49, # 2 p. 327 - 330
反应条件
triphenylphosphine in tetrahydrofuran
参考文献
Hoffmann-La Roche Inc.
Patent: US4983746 A1, 1991 ;
US 4983746 A
反应条件
1: 50 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature 2: 0.0015 g / hydrogen / 5percent Pd/C / tetrahydrofuran View Scheme
参考文献
Barbier; Schneider
Helvetica Chimica Acta, 1987 , vol. 70, # 1 p. 196 - 202
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran Ambient temperature;
参考文献
Helvetica Chimica Acta, , vol. 70, # 1 p. 196 - 202
反应条件
hydrogen bromide dampft zur Trockne ein, loest den Rueckstand im Bromwasserstoffsaeure, gibt Brom hinzu und leitet in die Loesung bei 0grad Stickoxyd ein; 2-bromo-4-methyl-valeric acid , d-form;
参考文献
Fischer,E.
Chemische Berichte, 1906 , vol. 39, p. 2930
参考文献
Fodor; Frankel
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1926 , vol. 159, p. 156
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 1.5 h; 0 deg C to RT;
参考文献
Pons, Jean-Marc; Pommier, Agnes; Lerpiniere, Joan; Kocienski, Philip
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 14 p. 1549 - 1552
参考文献
Journal of the American Chemical Society, , vol. 59, p. 2149
