1: ethyl bromide With magnesium in tetrahydrofuran Inert atmosphere; 2: 4-cyanotoluene With copper(l) iodide in tetrahydrofuran T=20°C; 10 h; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran T=0 - 20°C;
参考文献
Ueno, Satoshi; Shimizu, Ryosuke; Kuwano, Ryoichi
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4543 - 4545
Angewandte Chemie, 2009 , vol. 121, p. 4613 - 4615
water; oxygen; copper(l) iodide; palladium dichloride in N,N-dimethyl-formamide T=50°C; Wacker oxidation; 24 h; Title compound not separated from byproducts.;
