6,6’-二氯-2,2’-联吡啶合成路线 （共 21 条）
反应条件
ammonium tetrachlorozincate T=320 - 330°C;
参考文献
Ogawa, Shojiro; Shiraishi, Shinsaku
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2527 - 2530
反应条件
heated under N2 at 320-330°C for 6 h; starting material removed by sublimation, washed (H2O), treated with 10percent NaOH, washed (H2O), sublimation (200°C/0.5 mmHg, 3 h) for organic product, residue dissolved in 5percent aq. AcOH, pptd. (NaOH), recrystd. (AcOH), elem. anal.;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2527 - 2530
反应条件
1: With n-butyllithium; BuLi-LiDMAE in hexane
T=-20°C; Metallation; 1 h;
2: in tetrahydrofuran
T=-20 - 0°C; Substitution; 1 h;
参考文献
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Patent: US2010/298562 A1, 2010 ;
Location in patent: Page/Page column 34 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in xylene
Condensation; 12 h; Heating;
参考文献
Choppin, Sabine; Gros, Philippe; Fort, Yves
Organic Letters, 2000 , vol. 2, # 6 p. 803 - 805
反应条件
trichlorophosphate
T=95°C;
参考文献
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Patent: US2010/298562 A1, 2010 ;
Location in patent: Page/Page column 34 ;
反应条件
(2,2′-bipyridine)nickel(II) dibromide; sodium iodide in N,N-dimethyl-formamide
T=20°C; 3.3 h; Electrochemical reactionInert atmosphere;
参考文献
Oliveira, Jadson L.; Silva, Maria J.; Florencio, Tupolevck; Urgin, Karne; Sengmany, Stephane; Leonel, Eric; Nedelec, Jean-Yves; Navarro, Marcelo
Tetrahedron, 2012 , vol. 68, # 10 p. 2383 - 2390
反应条件
(2,2′-bipyridine)nickel(II) dibromide; sodium iodide in N,N-dimethyl-formamide
T=20°C; Electrochemical reactionInert atmosphere;
参考文献
Oliveira, Jadson L.; Silva, Maria J.; Florencio, Tupolevck; Urgin, Karne; Sengmany, Stephane; Leonel, Eric; Nedelec, Jean-Yves; Navarro, Marcelo
Tetrahedron, 2012 , vol. 68, # 10 p. 2383 - 2390
反应条件
copper(l) iodide; cesium fluoride in N,N-dimethyl-formamide
T=120°C; Hiyama Coupling; 12 h; Inert atmosphere;
参考文献
Gurung, Santosh K.; Thapa, Surendra; Vangala, Adarsh S.; Giri, Ramesh
Organic Letters, 2013 , vol. 15, # 20 p. 5378 - 5381
反应条件
potassium carbonate; [(P{(C6H11)3})2Pd(Cl)2] in tetrahydrofuran
T=150°C; carbonylative Suzuki cross-coupling; P=37503 Torr; 70 h;
参考文献
Couve-Bonnaire, Samuel; Carpentier, Jean-Francois; Mortreux, Andre; Castanet, Yves
Tetrahedron, 2003 , vol. 59, # 16 p. 2793 - 2799
反应条件
methylmagnesium bromide in diethyl ether
or THF;
参考文献
Uenishi; Tanaka; Wakabayashi; Oae; Tsukube
Tetrahedron Letters, 1990 , vol. 31, # 32 p. 4625 - 4628
