4-硫基-1H-吡啶并[3,4-d]嘧啶合成路线 （共 8 条）
反应条件
tetraphosphorus decasulfide in pyridine Heating;
参考文献
Moukha-Chafiq; Taha; Lazrek; Pannecouque; Witvrouw; De Clercq; Barascut; Imbach
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1797 - 1810
参考文献
Journal of the American Chemical Society, , vol. 78, p. 784,787
Journal of the American Chemical Society, , vol. 79, p. 6407,6413
反应条件
1: 78 percent / 0.8N NaOH / 0.42 h / 20 °C
2: 73 percent / K2CO3 / dimethylformamide / 20 °C
View Scheme
参考文献
Moukha-Chafiq; Taha; Lazrek; Pannecouque; Witvrouw; De Clercq; Barascut; Imbach
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1797 - 1810
反应条件
1: 63 percent / H2O / 888 h / 35 °C / purine nucleoside phosphorylase, uridine phosphorylase, K2HPO4, NaN3
2: 1.) Dowex 1-X8 (HCO3-form) / 1.) methanol, heating, 2.) 24 deg C, 20 h
View Scheme
参考文献
Krenitsky; Rideout; Koszalka; Inmon; Chao; Elion; Latter; Williams
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 32 - 35
反应条件
DOWEX AG 1-X8 in N,N-dimethyl-formamide
参考文献
Ballell, Lluis; Field, Robert A.; Chung, Gavin A.C.; Young, Robert J.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1736 - 1740
反应条件
1: 63 percent / H2O / 888 h / 35 °C / purine nucleoside phosphorylase, uridine phosphorylase, K2HPO4, NaN3
2: 1.) Dowex 1-X8 (HCO3-form) / 1.) methanol, heating, 2.) 24 deg C, 20 h
View Scheme
参考文献
Krenitsky; Rideout; Koszalka; Inmon; Chao; Elion; Latter; Williams
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 32 - 35
参考文献
Amersham Pharmacia Biotech UK Limited
Patent: US6600028 B1, 2003 ;
反应条件
in water
T=35°C; 888 h; purine nucleoside phosphorylase, uridine phosphorylase, K2HPO4, NaN3;
参考文献
Krenitsky; Rideout; Koszalka; Inmon; Chao; Elion; Latter; Williams
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 32 - 35
