反应条件
1: 93 percent / NaOMe / 5 h / Heating
2: 1) I2, KI, 20percent aq. NH4OH / 1) water, dioxane, 1 h, ice-water bath, 2) diphenyl ether, 4 h, 195 deg C
3: 89 percent / BBr3 / CH2Cl2 / 1) -22 deg C, 2 h, 2) r.t., 36 h
4: 97 percent / Cu2O, pyridine / 2 h / Heating; other alkynes, also with 8-iodoumbelliferone
5: 48 percent / conc. HCl / 24 h / 95 °C
View Scheme
参考文献
Zubia; Luis; Massanet; Collado
Tetrahedron, 1992 , vol. 48, # 20 p. 4239 - 4246
