可的松合成路线 - 魔法化学

50-23-7氢化可的松→53-06-5可的松+566-35-811-表氢化可的松+2899-95-820-羟基皮质醇

参考文献

Garcia-Rodriguez, L. K.; Krasnova, L. A.; Shner, V. F.; Messinova, O. V.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 10 p. 743 - 745
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 10 p. 73 - 75

152-58-9脱氧可的松→50-23-7氢化可的松+53-06-5可的松+566-35-811-表氢化可的松+595-18-614-alpha,17-alpha,21-三羟基孕甾-4-烯-3,20-二酮+2899-95-820-羟基皮质醇

参考文献

Garcia-Rodriguez, L. K.; Krasnova, L. A.; Shner, V. F.; Messinova, O. V.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 10 p. 743 - 745
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 10 p. 73 - 75

53-06-5可的松→382-45-6肾上腺甾酮

参考文献

Pinto, Rui M. A.; Salvador, Jorge A. R.; Le Roux, Christophe; Paixao, Jose A.
Journal of Organic Chemistry, 2009 , vol. 74, # 21 p. 8488 - 8491

53-06-5可的松→382-45-6肾上腺甾酮+3615-87-0(8S,9S,10R,13S,14S,17R)-17-[(1S)-1,2-二羟基乙基]-17-羟基-10,13-二甲基-1,2,6,7,8,9,12,14,15,16-十氢环戊烯并[a]菲-3,11-二酮

参考文献

Wilson, Maureen R.; Gallimore, Winklet A.; Reese, Paul B.
Steroids, 1999 , vol. 64, # 12 p. 834 - 843

53-06-5可的松+64-17-5乙醇→382-45-6肾上腺甾酮

参考文献

Mason
Journal of Biological Chemistry, 1938 , vol. 124, p. 475,478

53-06-5可的松+7664-93-9硫酸+67-64-1丙酮→382-45-6肾上腺甾酮

参考文献

Mason; Myers; Kendall
Journal of Biological Chemistry, 1936 , vol. 116, p. 267,275

53-06-5可的松+64-17-5乙醇+7664-93-9硫酸→382-45-6肾上腺甾酮+3597-46-4

参考文献

Mason
Journal of Biological Chemistry, 1938 , vol. 124, p. 475,478

53-06-5可的松+64-19-7醋酸→382-45-6肾上腺甾酮

参考文献

Reichstein
Helvetica Chimica Acta, 1936 , vol. 19, p. 1107,1125
Helvetica Chimica Acta, 1937 , vol. 20, p. 953,969, 978, 986

53-06-5可的松→53-36-1醋酸甲泼尼龙

参考文献

Fried et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 1235,1237

53-06-5可的松→50-23-7氢化可的松

参考文献

Meyer, Arne; Vuorinen, Anna; Zielinska, Agnieszka E.; Da Cunha, Thierry; Strajhar, Petra; Lavery, Gareth G.; Schuster, Daniela; Odermatt, Alex
Biochemical Pharmacology, 2013 , vol. 85, # 9 p. 1370 - 1378