N-[4-(甲基氨基)苯甲酰基]-L-谷氨酸合成路线 （共 10 条）
反应条件
1: iodine; KI; aqueous acetic acid / pH 3-3.5 2: aq. NaOH solution View Scheme
参考文献
Seeger et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 1753,1757
参考文献
Cosulich; Smith
Journal of the American Chemical Society, 1948 , vol. 70, p. 1922,1925
反应条件
iodine; acetic acid; potassium iodide pH 3-3.5;
参考文献
Seeger et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 1753,1757
反应条件
TMG in dimethyl sulfoxide
T=25°C; Acylation; 1 h;
参考文献
Luo, Jin; Smith, Michael D.; Lantrip, Douglas A.; Wang, Susan; Fuchs
Journal of the American Chemical Society, 1997 , vol. 119, # 42 p. 10004 - 10013
反应条件
1.1: sodium / 0 °C
1.2: 1 h / 0 °C
1.3: 79 percent / conc. HCl / 0 °C / pH 1
2.1: 100 percent / diethylamine / palladium tetrakistriphenylphosphine / CH2Cl2 / 3 h / 20 °C
3.1: 73 percent / tetramethylguanidine / dimethylsulfoxide / 1 h / 25 °C
View Scheme
参考文献
Luo, Jin; Smith, Michael D.; Lantrip, Douglas A.; Wang, Susan; Fuchs
Journal of the American Chemical Society, 1997 , vol. 119, # 42 p. 10004 - 10013
反应条件
1: 100 percent / diethylamine / palladium tetrakistriphenylphosphine / CH2Cl2 / 3 h / 20 °C
2: 73 percent / tetramethylguanidine / dimethylsulfoxide / 1 h / 25 °C
View Scheme
参考文献
Luo, Jin; Smith, Michael D.; Lantrip, Douglas A.; Wang, Susan; Fuchs
Journal of the American Chemical Society, 1997 , vol. 119, # 42 p. 10004 - 10013
反应条件
sodium hydroxide; copper
T=125°C;
参考文献
Cosulich; Smith
Journal of the American Chemical Society, 1948 , vol. 70, p. 1922,1925
反应条件
1: sodium nitrite; aqueous hydrochloric acid; aqueous potassium iodide solution / Diazotization
2: aq. NaOH solution; copper / 125 °C
View Scheme
参考文献
Cosulich; Smith
Journal of the American Chemical Society, 1948 , vol. 70, p. 1922,1925
反应条件
rat γ-glutamyl hydrolase; 2-hydroxyethanethiol in acetate buffer
T=37°C; pH=6.0; 3 h; Enzyme kinetics;
参考文献
Pankuch, Jessica J.; Coward, James K.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 12 p. 1561 - 1564
反应条件
in phosphate buffer
pH=7.8; Irradiation; Product distribution;
参考文献
Hirakawa, Kazutaka; Aoshima, Masahiro; Hiraku, Yusuke; Kawanishi, Shosuke
Photochemistry and Photobiology, 2002 , vol. 76, # 5 p. 467 - 472
