N-(2,6-二甲基苯基)-1-哌嗪乙酰胺合成路线 （共 12 条）
反应条件
in methanol T=25°C; RefluxLarge scale reaction;
参考文献
Organic Process Research and Development, , vol. 16, # 5 p. 748 - 754
反应条件
tetrabutyl ammonium fluoride in water T=20 - 60°C; 3 h;
参考文献
Kommi, Damodara N.; Kumar, Dinesh; Chakraborti, Asit K.
Green Chemistry, 2013 , vol. 15, # 3 p. 756 - 767
反应条件
N-ethyl-N,N-diisopropylamine in ethanol
反应条件
in ethanol 3 h; Reflux;
参考文献
ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD.; SHANGHAI KUOIKEE LABORATORIES CO., LTD.; Shi, Mingfeng; Li, Dan; Xu, Ling
Patent: US2013/90475 A1, 2013 ;
Location in patent: Paragraph 0029; 0030 ;
反应条件
2-hydroxymethylbenzoic acid in methanol Ugi Condensation; Reflux;
参考文献
La Spisa, Fabio; Feo, Alberto; Mossetti, Riccardo; Tron, Gian Cesare
Organic Letters, 2012 , vol. 14, # 23 p. 6044 - 6047
反应条件
in water T=80 - 110°C; 7 h;
参考文献
Kommi, Damodara N.; Kumar, Dinesh; Chakraborti, Asit K.
Green Chemistry, 2013 , vol. 15, # 3 p. 756 - 767
反应条件
1: sodium carbonate / dichloromethane / 1.5 h / 10 - 15 °C / Large scale reaction 2: methanol / 25 °C / Reflux; Large scale reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 5 p. 748 - 754
反应条件
potassium carbonate in ethanol; toluene 3 h; Reflux; SolventReagent/catalystTimeTemperature;
参考文献
ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD.; SHANGHAI KUOIKEE LABORATORIES CO., LTD.; Shi, Mingfeng; Li, Dan; Xu, Ling
Patent: US2013/90475 A1, 2013 ;
Location in patent: Paragraph 0047; 0048; 0049; 0050 ;
反应条件
potassium carbonate in methanol; toluene 4.5 h; Reflux; SolventReagent/catalystTemperature;
参考文献
ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD.; SHANGHAI KUOIKEE LABORATORIES CO., LTD.; Shi, Mingfeng; Li, Dan; Xu, Ling
Patent: US2013/90475 A1, 2013 ;
Location in patent: Paragraph 0035; 0036; 0037; 0038 ;
