反应条件
1: NaOMe / methanol / 12 h / 65 °C
2: H2SO4 / 24 h / 65 °C
3: 78 percent / 1,3-dibromo-5,5-dimethylhydantoin, (PhCO)2O2 / CCl4 / 5 h / Heating
4: 89 percent / H2SO4 / 16 h / Heating
5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 1 h
6: t-BuOK / 1,2-dimethoxy-ethane; toluene / 5 h / 25 °C
7: TiCl4, Et3N / CH2Cl2 / 1 h / 25 °C
8: benzene / 12 h / 25 °C
9: 79 percent / Et3N / toluene / 4 h / -10 °C
10: 1.) HBr, 2.) K2CO3 / 1.) CF3CH2OH, 80 deg C, 24 h, 2.) CF3CH2OH, 25 deg C, 1 h
View Scheme
参考文献
Boger, Dale L.; Hong, Jiyong
Journal of the American Chemical Society, 1998 , vol. 120, # 6 p. 1218 - 1222
