N,4-二甲氧基-N-甲基苯甲酰胺合成路线 （共 14 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane Inert atmosphere;
参考文献
Hayashi, Yoshio; Yamazaki, Yuri; Sumikura, Makiko; Masuda, Yurika; Hayashi, Yoshiki; Yasui, Hiroyuki; Kiso, Yoshiaki; Chinen, Takumi; Usui, Takeo; Yakushiji, Fumika; Potts, Barbara; Neuteboom, Saskia; Palladino, Michael; Lloyd, George Kenneth
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4279 - 4289
反应条件
in tetrahydrofuran T=0 - 20°C; 0.5 h; Yield given;
参考文献
Lee, Na Ra; Lee, Jae In
Synthetic Communications, 1999 , vol. 29, # 8 p. 1249 - 1255
反应条件
1: propargyl bromide With magnesium; mercury dichloride in diethyl ether 1.5 h; Inert atmosphere; 2: N-methoxy-N-methyl-4-methoxy-benzamide in diethyl ether T=0°C; 1.5 h; Inert atmosphere;
参考文献
Davis, Lindsey O.; Tobey, Suzanne L.
Tetrahedron Letters, 2010 , vol. 51, # 47 p. 6078 - 6081
反应条件
1.1: cesium fluoride / toluene / 0.17 h / 0 °C 1.2: 24 h / 0 - 20 °C 2.1: tetrabutyl ammonium fluoride; water / toluene; tetrahydrofuran / 2 h / 50 °C View Scheme
参考文献
Rudzinski, Diandra M.; Kelly, Christopher B.; Leadbeater, Nicholas E.
Chemical Communications, 2012 , vol. 48, # 77 p. 9610 - 9612
反应条件
1: 2-picoline With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: N-methoxy-N-methyl-4-methoxy-benzamide in tetrahydrofuran; hexane T=-78°C; 3 h; Inert atmosphere;
参考文献
Muir, Calum W.; Kennedy, Alan R.; Redmond, Joanna M.; Watson, Allan J. B.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3337 - 3340
反应条件
N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine in N,N-dimethyl-formamide T=100°C;
参考文献
Cutulic, Sylvain P. Y.; Murphy, John A.; Farwaha, Hardeep; Zhou, Sheng-Ze; Chrystal, Ewan
Synlett, 2008 , # 14 p. 2132 - 2136
反应条件
1: 2-fluoro-pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-70°C; 0.5 h; 2: N-methoxy-N-methyl-4-methoxy-benzamide in tetrahydrofuran; hexane T=-70 - -60°C;
参考文献
Beutner, Gregory L.; Kuethe, Jeffrey T.; Yasuda, Nobuyoshi
Tetrahedron Letters, 2009 , vol. 50, # 7 p. 781 - 784
反应条件
in tetrahydrofuran T=-78 - 20°C;
参考文献
KARO BIO AB; WENNERSTAaL, Mattias; LOeFSTEDT, Joakim; WU, Xiongyu; KRUeGER, Lars; HAGBERG, Lars
Patent: WO2011/42477 A1, 2011 ;
Location in patent: Page/Page column 40; 41 ;
WO 2011/042477 A1
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere; 2: With ammonia; iodine in tetrahydrofuran; hexane; water T=0 - 20°C; Inert atmosphere;
参考文献
Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814
反应条件
in tetrahydrofuran; hexane
T=0 - 20°C; 0.5 h; Yield given;
参考文献
Lee, Na Ra; Lee, Jae In
Synthetic Communications, 1999 , vol. 29, # 8 p. 1249 - 1255
