1-溴-4,5-二甲氧基-2-甲基苯合成路线 （共 12 条）
反应条件
1: permanganate; diluted NaOH-solution 2: nitric acid View Scheme
参考文献
Heap; Jones; Robinson
Journal of the Chemical Society, 1927 , p. 2022
反应条件
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.08 h / -78 °C 1.2: 0.33 h / -78 °C 2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 12 h / -78 - 20 °C 3.1: trifluoroacetic acid / methanol / 3 h / 0 °C 4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.25 h / -78 °C View Scheme
参考文献
Mastranzo, Virginia M.; Yuste, Francisco; Ortiz, Benjamin; Sanchez-Obregon, Ruben; Toscano, Ruben A.; Garcia Ruano, Jose L.
Journal of Organic Chemistry, 2011 , vol. 76, # 12 p. 5036 - 5041
反应条件
hydrogen bromide; acetic acid
参考文献
Tomita et al.
Yakugaku Zasshi, 1956 , vol. 76, p. 1122,1125
Chem.Abstr., 1957 , p. 3505
反应条件
N-bromosuccinmide in tetrachloromethane T=20°C; Wohl-Ziegler Bromination; 6 h; Irradiation;
参考文献
Tsuchiya, Daisuke; Kawagoe, Yuhsuke; Moriyama, Katsuhiko; Togo, Hideo
Organic Letters, 2013 , vol. 15, # 16 p. 4194 - 4197
反应条件
nitric acid; acetic anhydride
参考文献
Heap; Jones; Robinson
Journal of the Chemical Society, 1927 , p. 2022
参考文献
Heap; Jones; Robinson
Journal of the Chemical Society, 1927 , p. 2022
反应条件
1: 1-Bromo-3,4-dimethoxy-6-methylbenzene With tert.-butyl lithium in tetrahydrofuran
T=-78°C; 1 h;
2: carbon dioxide in tetrahydrofuran
Further stages.;
参考文献
Fukuda, Tsutomu; Iwao, Masatomo
Heterocycles, 2007 , vol. 74, # C p. 701 - 720
反应条件
magnesium
1.) THF; Multistep reaction;
参考文献
Charlton; Koh; Plourde
Canadian Journal of Chemistry, 1990 , vol. 68, # 11 p. 2028 - 2032
反应条件
in N,N-dimethyl-formamide
T=120°C; 16 h;
参考文献
Davis, Franklin A.; Mohanty, Pradyumna K.
Journal of Organic Chemistry, 2002 , vol. 67, # 4 p. 1290 - 1296
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide
T=20°C; 1 h;
参考文献
Fukuda, Tsutomu; Iwao, Masatomo
Heterocycles, 2007 , vol. 74, # C p. 701 - 720
