(1,3-二氧戊环-2-基)甲基三苯基溴化瞵合成路线 （共 22 条）
反应条件
in toluene 24 h; Heating / reflux;
参考文献
Das, Biswajit; Salman, Mohammad; Kurhade, Santosh Haribhau; Venkataramanan, Ramadass; Kumar, Rajesh; Kapkoti, Gobind Singh; Katoch, Rita; Bandyopadhyay, Anish; Rattan, Ashok
Patent: US2009/170790 A1, 2009 ;
Location in patent: Page/Page column 23 ;
反应条件
1: (1,3-dioxolan-2-yl)-methyl-triphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran T=0°C; 0.5 h; Inert atmosphere; 2: 5‐[(tert‐butyldiphenylsilyl)oxy]pentanal in tetrahydrofuran T=0 - 20°C; 0.6 h; Inert atmosphere; 3: With oxalic acid in tetrahydrofuran; water 1.5 h;
参考文献
Pohjakallio, Antti; Pihko, Petri M.
Chemistry - A European Journal, 2009 , vol. 15, # 16 p. 3960 - 3964
反应条件
1: With potassium carbonate; tri[2-(2-methoxyethoxy)ethyl]amine in dichloromethane; water 6 h; Heating / reflux; 2: With water; hydrogenchloride in tetrahydrofuran T=20°C; 2 h; 3: With sodium hydroxide in tetrahydrofuran; water T=0°C;
参考文献
Henninger, Todd C.; Macielag, Mark J.; Marinelli, Brett A.; Zhu, Bin
Patent: US2004/18994 A1, 2004 ;
Location in patent: Page/Page column 59 ;
反应条件
potassium hexamethylsilazane in tetrahydrofuran T=20°C; 2 h;
参考文献
H. LUNDBECK A/S
Patent: WO2005/16884 A1, 2005 ;
Location in patent: Page/Page column 66-67 ;
WO 2005/016884 A1
反应条件
1: With manganese(IV) oxide; 1-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene; 4 A molecular sieve in tetrahydrofuran in situ oxidation-Wittig reaction; 24 h; Heating; 2: With hydrogenchloride in tetrahydrofuran Further stages.;
参考文献
Chemical Communications, , # 18 p. 2284 - 2285
反应条件
1: With manganese(IV) oxide; 1-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene; 4 A molecular sieve in tetrahydrofuran in situ oxidation-Wittig reaction; 24 h; Heating; 2: With hydrogenchloride in tetrahydrofuran Further stages.;
参考文献
Chemical Communications, , # 18 p. 2284 - 2285
反应条件
1: With tri[2-(2-methoxyethoxy)ethyl]amine; potassium carbonate in dichloromethane; water
T=20°C; 18 h;
2: With hydrogenchloride in dichloromethane; water
T=20°C;
参考文献
METHYLGENE INC.
Patent: WO2004/35525 A1, 2004 ;
Location in patent: Page 43 ;
反应条件
hydrogenchloride; potassium carbonate; tri[2-(2-methoxyethoxy)ethyl]amine
1.) dichloromethane, room temperature, 12 h, 2.) dichloromethane, room temperature, 12 h; Yield given. Multistep reaction;
参考文献
Daubresse; Francesch; Mhamdi; Rolando
Synthesis, 1994 , # 4 p. 369 - 371
反应条件
n-butyllithium in ethylene glycol dimethyl ether; hexane
1 h; Ambient temperature;
参考文献
Eitel, Manfred; Pindur, Ulf
Synthesis, 1989 , # 5 p. 364 - 367
反应条件
1: With 18-crown-6 ether; sodium hydride in tetrahydrofuran
T=20°C; Wittig reaction;
2: With hydrogenchloride in tetrahydrofuran
T=20°C; 2 h;
参考文献
Plazuk, Damian; Janowska, Izabela; Klys, Arkadiusz; Hameed, Asia; Zakrzewski, Janusz
Synthetic Communications, 2003 , vol. 33, # 3 p. 381 - 385
