2-氨基-6-氯-3-氰基吡啶合成路线 （共 7 条）
反应条件
water; sodium hydroxide 1 h; Reflux;
参考文献
Kim, Hyo-Joong; Chen, Fei; Benner, Steven A.
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3664 - 3669
反应条件
water; sodium hydroxide 1 h; Reflux;
参考文献
Kim, Hyo-Joong; Chen, Fei; Benner, Steven A.
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3664 - 3669
反应条件
pyridine; trifluoroacetic anhydride in 1,4-dioxane
T=0 - 60°C;
参考文献
BAYER HEALTHCARE AG
Patent: US2009/258877 A1, 2009 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1.1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran / -78 - -10 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 4 h / 20 °C
3.1: hydrogenchloride / 1,4-dioxane / 0.5 h
4.1: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 0 - 60 °C
View Scheme
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2011/190316 A1, 2011 ;
US 20110190316 A1
反应条件
1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 4 h / 20 °C
2: hydrogenchloride / 1,4-dioxane / 0.5 h
3: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 0 - 60 °C
View Scheme
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2011/190316 A1, 2011 ;
US 20110190316 A1
反应条件
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
2.1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran / -78 - -10 °C / Inert atmosphere
2.2: -78 - 20 °C
3.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 4 h / 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 0.5 h
5.1: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 0 - 60 °C
View Scheme
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2011/190316 A1, 2011 ;
US 20110190316 A1
反应条件
1: hydrogenchloride / 1,4-dioxane / 0.5 h
2: trifluoroacetic anhydride; pyridine / 1,4-dioxane / 0 - 60 °C
View Scheme
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2011/190316 A1, 2011 ;
US 20110190316 A1
