2-(6-甲基吡啶-3-基)乙腈合成路线 （共 4 条）
反应条件
in dimethyl sulfoxide
T=45 - 60°C; 0.25 h; Inert atmosphere;
参考文献
MEDIVATION TECHNOLOGIES, INC.; CHAKRAVARTY, Sarvajit; HART, Barry, Patrick; JAIN, Rajendra, Parasmal
Patent: WO2011/103460 A1, 2011 ;
Location in patent: Page/Page column 228 ;
反应条件
1: SOCl2 / 4 h / 20 °C
2: 1.8 g / dimethylsulfoxide / 1 h / 100 °C
View Scheme
参考文献
Chen, Chen; Wilcoxen, Keith M.; Huang, Charles Q.; Xie, Yun-Feng; McCarthy, James R.; Webb, Thomas R.; Zhu, Yun-Fei; Saunders, John; Liu, Xin-Jun; Chen, Ta-Kung; Bozigian, Haig; Grigoriadis, Dimitri E.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4787 - 4798
反应条件
1: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
2: SOCl2 / 4 h / 20 °C
3: 1.8 g / dimethylsulfoxide / 1 h / 100 °C
View Scheme
参考文献
Chen, Chen; Wilcoxen, Keith M.; Huang, Charles Q.; Xie, Yun-Feng; McCarthy, James R.; Webb, Thomas R.; Zhu, Yun-Fei; Saunders, John; Liu, Xin-Jun; Chen, Ta-Kung; Bozigian, Haig; Grigoriadis, Dimitri E.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4787 - 4798
反应条件
in dimethyl sulfoxide
T=100°C; 1 h;
参考文献
Chen, Chen; Wilcoxen, Keith M.; Huang, Charles Q.; Xie, Yun-Feng; McCarthy, James R.; Webb, Thomas R.; Zhu, Yun-Fei; Saunders, John; Liu, Xin-Jun; Chen, Ta-Kung; Bozigian, Haig; Grigoriadis, Dimitri E.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4787 - 4798
