反应条件
1: (COCl)2, DMF / benzene / 3 h / Ambient temperature
2: pyridine / Ambient temperature
3: 1.) N-isopropylcyclohexylamine, n-BuLi / 1.) THF, hexane, - 78 deg C, 1 h, 2.) THF, hexane, MeOH, reflux, overnight
4: 78 percent / ClCH2COOH, / H2O / 100 °C
5: 0.75 h / 140 °C
View Scheme
参考文献
Fenick, David J.; Falvey, Daniel E.
Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 4791 - 4799
