5-硝基-2,6-二氧-1,2,3,6-四氢嘧啶-4-羧酸乙酯合成路线 （共 8 条）
反应条件
N,N-dimethyl-aniline; trichlorophosphate 1.) 30 min, 2.) reflux, 1 h;
参考文献
Boyle, Peter H.; Gillespie, Paul
Journal of Chemical Research, Miniprint, 1989 , # 9 p. 2086 - 2097
反应条件
1: 68 percent / NaHCO3, Na2S2O4 / H2O / 1.5 h / Ambient temperature
2: 93 percent / 1.75 h / Heating
3: 72 percent / saturated ethanolic ammonia / 1.) room temperature, 3 h, 2.) reflux, 2.5 h;
4: 22 percent / anhydrous potassium carbonate / 4.5 h / Heating
View Scheme
参考文献
Pendergast; Hall
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 5 p. 1411 - 1413
反应条件
sulfuric acid
8 h; Heating / reflux;
参考文献
SYNGENTA LIMITED; SYNGENTA PARTICIPATIONS AG
Patent: WO2004/56826 A1, 2004 ;
Location in patent: Page 74 ;
反应条件
sulfuric acid
9 h; Heating;
参考文献
Boyle, Peter H.; Gillespie, Paul
Journal of Chemical Research, Miniprint, 1989 , # 9 p. 2086 - 2097
反应条件
sulfuric acid
10 h; Heating;
参考文献
Boyle, Peter H.; Gillespie, Paul
Journal of Chemical Research, Miniprint, 1989 , # 9 p. 2086 - 2097
参考文献
Koehler
Justus Liebigs Annalen der Chemie, 1886 , vol. 236, p. 50
反应条件
1: 83 percent / conc. H2SO4, fuming HNO3 (d 1.5) / 0 °C
2: 91 percent / fuming HNO3 (d 1.5) / 4 h / 100 °C
3: 97 percent / conc. H2SO4 / 9 h / Heating
View Scheme
参考文献
Boyle, Peter H.; Gillespie, Paul
Journal of Chemical Research, Miniprint, 1989 , # 9 p. 2086 - 2097
反应条件
1: 91 percent / fuming HNO3 (d 1.5) / 4 h / 100 °C
2: 97 percent / conc. H2SO4 / 9 h / Heating
View Scheme
参考文献
Boyle, Peter H.; Gillespie, Paul
Journal of Chemical Research, Miniprint, 1989 , # 9 p. 2086 - 2097
