1: 4-iodobenzoic acid ethyl ester With isopropylmagnesium chloride in tetrahydrofuran T=-40°C; 0.916667 h; 2: With lithium chloride; manganese (II) chloride in tetrahydrofuran T=-40°C; 3: 2-chlorobenzophenone in tetrahydrofuran T=0°C; 2 h;
palladium diacetate in N,N-dimethyl-formamide T=50°C; Negishi coupling; 16 h; Title compound not separated from byproducts;
参考文献
Alimardanov, Asaf; Schmieder-Van De Vondervoort, Lizette; De Vries, Andre H. M.; De Vries, Johannes G.
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1812 - 1817