(2-甲基苯甲酰)乙酸乙酯合成路线 （共 14 条）
反应条件
1: carbonic acid diethyl ester With sodium hydride in toluene; mineral oil T=20°C; 0.25 h; Inert atmosphere; 2: (R)-methylphenylacetoaldehyde in toluene; mineral oil 18 h; RefluxInert atmosphere;
参考文献
Genentech, Inc.
Patent: US2012/22043 A1, 2012 ;
Location in patent: Page/Page column 89 ;
US 20120022043 A1
反应条件
[CpFe(CO)2(THF)][BF4] in dichloromethane T=0°C; 14 h;
参考文献
Dudley, Matthew E.; Morshed, Monzur; Brennan, Courtney L.; Islam, M. Shahidul; Ahmad, M. Syarhabil; Atuu, Mary-Rose; Branstetter, Bryan; Hossain, M. Mahmun
Journal of Organic Chemistry, 2004 , vol. 69, # 22 p. 7599 - 7608
反应条件
copper(II) sulfate T=20°C; 39 h;
参考文献
Liao, Mingyi; Wang, Jianbo
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8859 - 8861
反应条件
dichloro(cycloocta-1,5-diene)palladium(II); N,N-dicyclohexylmethylamine; triethylamine; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; magnesium chloride; [(t-Bu)3PH]BF4 in 1,4-dioxane T=80°C; 18 h; Inert atmosphereGlovebox;
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Skrydstrup, Troels
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9763 - 9766
Angew. Chem., 2013 , vol. 125, # 37 p. 9945 - 9948
反应条件
sodium ethanolate T=0 - 5°C;
参考文献
Zhu, Youquan; Zou, Xiaomao; Hu, Fangzhong; Yao, Changsheng; Liu, Bin; Yang, Huazheng
Journal of Agricultural and Food Chemistry, 2005 , vol. 53, # 24 p. 9566 - 9570
反应条件
ammonium hydroxide; sodium hydroxide; water; ammonium chloride T=50°C; 3 h;
参考文献
Sicker, Dieter; Mann, Gerhard
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 4 p. 839 - 850
反应条件
1.1: 74 percent / DBU / H2O / 24 h / 20 °C 2.1: triethylamine / CH2Cl2 / 0.08 h / 0 °C 2.2: CH2Cl2 / 2 h / 0 - 20 °C 3.1: Rh2(OAc)4 / CH2Cl2 / 20 °C 3.2: 97 percent / silica gel View Scheme
参考文献
Xiao, Fengping; Liu, Yu; Wang, Jianbo
Tetrahedron Letters, 2007 , vol. 48, # 7 p. 1147 - 1149
反应条件
N-cyclohexyl-N-isopropylamine; ethylmagnesium bromide in diethyl ether 3 h;
参考文献
Janda, Miroslav; Srogl, Jan; Dvorakova, Hana; Dvorak, Dalimil; Stibor, Ivan
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 4 p. 906 - 916
反应条件
n-butyllithium; diisopropylamine Ambient temperature;
参考文献
Hornback, Joseph M.; Poundstone, Melani L.; Vadlamani, Bhanumathi; Graham, Susan M.; Gabay, Julie; Patton, Shelly T.
Journal of Organic Chemistry, 1988 , vol. 53, # 24 p. 5597 - 5601
反应条件
n-butyllithium 1.) THF, 2,2'-bipyridyl, hexane, -78 to -5 deg C, 3 min.; 2.) - 5 to 20 deg C within 1 h; Yield given. Multistep reaction;
参考文献
Brown; Coulston; Eastwood; Moffat
Tetrahedron, 1992 , vol. 48, # 36 p. 7763 - 7774
