α-乙酰基-γ-丁内酯合成路线 （共 116 条）
反应条件
boron trifluoride diethyl etherate in isopropyl mesylate T=20°C; 72.25 h;
参考文献
SENEXIS LIMITED; SCOPES, David; HORWELL, David
Patent: WO2011/42497 A1, 2011 ;
Location in patent: Page/Page column 5 ;
WO 2011/042497 A1
反应条件
1: 88 percent / BF3*MeOH / ethanol / 72 h / Ambient temperature 2: 89 percent / Et3N / H2O / 18 h / Ambient temperature View Scheme
参考文献
Sato, Yasunobu; Shimoji, Yasuo; Fujita, Hiroshi; Nishino, Hiroshi; Mizuno, Hiroshi; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 927 - 937
反应条件
1: hydrogenchloride; hydrogen; trichlorophosphate / toluene; cyclohexane; acetic acid 2: sodium borohydride / dichloromethane; methanol View Scheme
参考文献
Xu, Weichu; Wright, George E.; Yanachkova, Milka; Yanachkov, Ivan B.
Letters in Organic Chemistry, 2014 , vol. 11, # 6 p. 470 - 473
反应条件
1: With toluene-4-sulfonic acid in methoxybenzene Reflux; 2: With trichlorophosphate in methoxybenzene T=25 - 110°C;
参考文献
ORCHID CHEMICALS and PHARMACEUTICALS LIMITED
Patent: US2010/298566 A1, 2010 ;
Location in patent: Page/Page column 6 ;
反应条件
3,3-dimethyldioxirane; nickel diacetate in water; acetone 3.5 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 52, # 16 p. 5799 - 5804
反应条件
oxygen; cerium(III) chloride in isopropyl alcohol T=23°C; 16 h;
参考文献
European Journal of Organic Chemistry, , # 24 p. 4879 - 4886
反应条件
1: 89 percent / SO2Cl2 2: HCl / acetic acid / Heating View Scheme
参考文献
Herbert, John M.; Le Strat, Franck; Oumeddour, Delphine G.; Passey, Stephen C.; Taylor, Keith; Whitehead, David M.
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 2 p. 89 - 92
反应条件
ammonium acetate T=130 - 140°C; 1 h;
参考文献
Badawey, E.; Kappe, T.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 4 p. 327 - 332
反应条件
ammonium acetate in ethanol 15 h; Heating;
参考文献
Badawey, El-Sayed A. M.; El-Ashmawey, Ibrahim M.
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 5 p. 349 - 361
反应条件
hydrazine hydrate in acetonitrile Ring cleavage; cyclocondensation; 2 h; Heating;
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 11 p. 967 - 976
