α-乙酰基-γ-丁内酯合成路线 （共 116 条）
反应条件
sodium hydroxide in ethanol; water T=200°C; 2 h;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 24, p. 1607 - 1608
Zhurnal Organicheskoi Khimii, , vol. 24, # 8 p. 1782 - 1783
反应条件
1-methyl-pyrrolidin-2-one; sodium iodide T=170°C; 3 h;
参考文献
Weber, Walter; Meijere, Armin de
Synthetic Communications, 1986 , vol. 16, # 7 p. 837 - 846
反应条件
hydrazine hydrate in water Ring cleavage; cyclocondensation; 2 h; Heating;
参考文献
Zimmermann, Diane; Janin, Yves Louis; Brehm, Lotte; Braeuner-Osborne, Hans; Ebert, Bjarke; Johansen, Tommy Norskov; Madsen, Ulf; Krogsgaard-Larsen, Povl
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 11 p. 967 - 976
反应条件
hydrogenchloride; sodium hydrogencarbonate; sodium chloride in hexane; water T=110 - 115°C; pH=7.2; 10 h; Large scale;
参考文献
Fleck, Thomas J.; Chen, Jiong Jack; Lu, Cuong V.; Hanson, Kari J.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 334 - 338
参考文献
Ing et al.
British Journal of Pharmacology and Chemotherapy, 1952 , vol. 7, p. 103,114
参考文献
Korte; Buechel
Chemische Berichte, 1959 , vol. 92, p. 877,881
Full Text Show Details
Korte; Buechel
Angewandte Chemie, 1959 , vol. 71, p. 709,722
反应条件
1: toluene-4-sulfonic acid / toluene / Reflux 2: trichlorophosphate / 1 h / Reflux 3: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Krishnamurthy, Byregowda; Vinaya, Kambappa; Prasanna, Doddakunche S.; Raghava, Byregowda; Rangappa, Kanchugarakoppal S.
Letters in Drug Design and Discovery, 2011 , vol. 8, # 10 p. 988 - 995
反应条件
1: in cyclohexane 0.5 - 0.666667 h; 2: With sulfuric acid in cyclohexane 30 h; Heating / reflux;
参考文献
NATCO PHARMA LIMITED
Patent: WO2009/10988 A1, 2009 ;
Location in patent: Page/Page column 12 ;
参考文献
Badawey; Kappe
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 10 p. 815 - 822
反应条件
1: 3-acetyltetrahydrofuran-2-one With sodium methylate in benzene 2: methyl iodide Further stages.;
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 4 p. 379 - 389
