N-亚苄基-4-甲基苯磺酰胺合成路线 （共 129 条）
反应条件
1: 1.) n-butyllithium / 1.) hexane, THF, -100 deg C, 15 min, 2.) THF, -85 to -100 deg C, 6 h 2: 44 percent / p-TsOH, conc. HCl / methanol; H2O / 96 h / Heating 3: 86 percent / LiAlH4 / tetrahydrofuran / 16 h / Heating 4: 75 percent / Na, liquid ammonia / tetrahydrofuran / 0.75 h / -78 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 2 p. 503 - 517
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / -40 °C 1.2: 67 percent / tetrahydrofuran; hexane / 2 h / -40 - -20 °C 2.1: 73 percent / O3 / -78 °C View Scheme
参考文献
Amombo, Marlyse Okala; Hausherr, Arndt; Reissig, Hans-Ulrich
Synlett, 1999 , # 12 p. 1871 - 1874
反应条件
(η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate in tetrahydrofuran; toluene T=40°C; Mannich type reaction; 15 h; Inert atmosphereMolecular sieve; optical yield given as percent dediastereoselective reaction;
参考文献
Bartoszewicz, Agnieszka; Jezowska, Martina M.; Laymand, Kevin; Moebus, Juri; Martin-Matute, Belen
European Journal of Inorganic Chemistry, 2012 , # 9 p. 1517 - 1530
反应条件
1: 1.) LDA / 1.) cyclohexane, THF, - 78 deg C, 15 min, 2.) THF, - 78 deg C -> 25 deg C, 4 h 2: 78 percent / t-BuOK / dimethylformamide / 85 °C View Scheme
参考文献
Katritzky, Alan R.; Gordeev, Mikhail F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 11 p. 1295 - 1298
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; potassium tert-butylate; triphenylphosphine in tetrahydrofuran T=40°C; 15 h; Molecular sieve; optical yield given as percent de;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 16 p. 2657 - 2666
反应条件
1: CH2=CHCH2PPh3(1+)*Br(1-) in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: N-benzylidene-4-methylbenzenesulfonamide in tetrahydrofuran; hexane T=-78 - 20°C; 12 h; Inert atmosphere; optical yield given as percent destereoselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 132, # 14 p. 5018 - 5020
反应条件
formic acid; C6H15N*C31H37ClN2O2RhS*ClH; triethylamine in ethyl acetate Inert atmosphere;
参考文献
Kwak, Se Hun; Lee, Sun Ah; Lee, Kee-In
Tetrahedron Asymmetry, 2010 , vol. 21, # 7 p. 800 - 804
反应条件
1: 2-monochloropropane With zinc(II) chloride in tetrahydrofuran T=20°C; 1 h; 2: [N(E)]-4-methyl-N-(phenylmethylene)benzenesulfonamide in tetrahydrofuran T=20°C; 2 h;
参考文献
Journal of the American Chemical Society, , vol. 128, # 31 p. 9998 - 9999
反应条件
1: ethyl magnesium chloride With zinc(II) chloride in tetrahydrofuran T=20°C; 1 h; 2: [N(E)]-4-methyl-N-(phenylmethylene)benzenesulfonamide in tetrahydrofuran T=20°C; 2 h;
参考文献
Journal of the American Chemical Society, , vol. 128, # 31 p. 9998 - 9999
反应条件
acetic acid in dichloromethane T=20°C; 16 h; Molecular sieve;
参考文献
Organic Letters, , vol. 14, # 1 p. 82 - 85
