2-乙氧基-3-(4-硝基苯基)-丙烯酸乙酯合成路线 （共 5 条）
反应条件
1: With sodium hydroxide; water in isopropyl mesylate
T=20°C; 18 h;
2: With hydrogenchloride in isopropyl mesylate; water
参考文献
Nogra Pharma Limited; NACCARI, Giancarlo; BARONI, Sergio
Patent: EP1910270 B1, 2013 ;
Location in patent: Paragraph 0084; 0087; 0103; 0106 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=18°C; 18 h;
参考文献
Naccari, Giancarlo; Baroni, Sergio
Patent: US2009/48343 A1, 2009 ;
Location in patent: Page/Page column 9-10; 12 ;
反应条件
1: 2-diethylphosphono-2-ethoxyacetic acid ethyl ester With sodium hydride in tetrahydrofuran
T=0°C;
2: 4-nitrobenzaldehdye in tetrahydrofuran
T=0 - 20°C; 16 h;
参考文献
DR. REDDY'S LABORATORIES LIMITED
Patent: US2003/229083 A1, 2003 ;
Location in patent: Page 21 ;
反应条件
1: acetic anhydride; sodium acetate / 6 h / 120 °C
2: hydrogenchloride; water / 6 h / 100 °C
3: caesium carbonate / N,N-dimethyl-formamide / 18 h / 18 °C
View Scheme
参考文献
Nogra Pharma Limited; NACCARI, Giancarlo; BARONI, Sergio
Patent: EP1910270 B1, 2013 ;
反应条件
1: hydrogenchloride; water / 6 h / 100 °C
2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 18 °C
View Scheme
参考文献
Nogra Pharma Limited; NACCARI, Giancarlo; BARONI, Sergio
Patent: EP1910270 B1, 2013 ;
