2-甲基-1,4-苯二甲酸合成路线 （共 38 条）
反应条件
sodium hydroxide; water in diethylene glycol 42 h; Heating;
参考文献
Anzalone, Luigi; Hirsch, Jerry A.
Journal of Organic Chemistry, 1985 , vol. 50, # 12 p. 2128 - 2133
反应条件
1: 1,4-dibromo-2-methylbenzene With n-butyllithium in hexane T=60°C; 20 h; 2: carbon dioxide in diethyl ether; hexane T=20°C;
参考文献
ALANTOS PHARMACEUTICALS, INC.
Patent: WO2006/116157 A2, 2006 ;
Location in patent: Page/Page column 77 ;
WO 2006/116157 A2
反应条件
oxygen; anhydrous cobalt diacetate; Manganese (II) acetate; ZrO(OAc)2; 2,6-dihydroxypyromellitimide in acetic acid T=80 - 120°C; P=6000.6 Torr; 2 h;
参考文献
US2011/71314 A1, ;
Page/Page column 14 ;
反应条件
potassium acetate; phthalic acid dipotassium salt; zinc oxide T=450°C; Henkel Reaction; P=25858.1 Torr;
参考文献
Mossi and Ghisolfi International S.A.
Patent: EP1232136 B1, 2005 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: 1,4-dibromo-2-methylbenzene With magnesium; ethylene dibromide in tetrahydrofuran T=60°C; 15 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran T=-78 - 20°C; Inert atmosphere;
参考文献
Uemura, Takashi; Ono, Yukari; Hijikata, Yuh; Kitagawa, Susumu
Journal of the American Chemical Society, 2010 , vol. 132, # 13 p. 4917 - 4924
反应条件
oxygen; acetic acid; 1,3,5-trihydroxyhexahydro-1,3,5-triazine-2,4,6-trione; anhydrous cobalt diacetate; Manganese (II) acetate T=100°C; P=760 Torr; 1 h; Further byproducts given;
参考文献
Tetrahedron, , vol. 62, # 28 p. 6695 - 6699
参考文献
Hidefumi Hirai
Patent: US5319134 A1, 1994 ;
参考文献
Hidefumi Hirai
Patent: US5319134 A1, 1994 ;
反应条件
n-butyllithium; Petroleum ether anschliessendes Behandeln mit festem Kohlendioxid;
参考文献
Journal of the American Chemical Society, , vol. 62, p. 2327,2333
反应条件
1: 80 percent / N-methylpyrrolidone / various solvent(s) / 24 h / Heating 2: 94 percent / NaOH, H2O / bis-(2-hydroxy-ethyl) ether / 42 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 12 p. 2128 - 2133
