N-苯甲酰基-5’-O-叔-丁基二甲基甲硅烷-2’-脱氧胞啶合成路线 （共 9 条）
反应条件
1H-imidazole in N,N-dimethyl-formamide
T=0°C; 3 h; Inert atmosphere;
参考文献
Lucas; Elchinger; Faugeras; Zerrouki
Nucleosides, Nucleotides and Nucleic Acids, 2010 , vol. 29, # 3 p. 168 - 177
反应条件
1H-imidazole in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Igolen, Jean; Morin, Christophe
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4802 - 4804
反应条件
1: pyridine / 15 h / 80 °C
2: 49 percent / imidazole / dimethylformamide / Ambient temperature
View Scheme
参考文献
Igolen, Jean; Morin, Christophe
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4802 - 4804
反应条件
1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 1.) 22 deg C, 1 h, 2.) r.t., 24 h
2: NaHCO3 / methanol
3: imidazole / dimethylformamide
View Scheme
参考文献
Koga; Wilk; Moore; Scremin; Zhou; Beaucage
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1520 - 1530
反应条件
1: pyridine / 15 h / 80 °C
2: 49 percent / imidazole / dimethylformamide / Ambient temperature
View Scheme
参考文献
Igolen, Jean; Morin, Christophe
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4802 - 4804
反应条件
1: 90 percent / pyridine / 5 h / 80 °C
2: 49 percent / imidazole / dimethylformamide / Ambient temperature
View Scheme
参考文献
Igolen, Jean; Morin, Christophe
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4802 - 4804
反应条件
1: 90 percent / dicyclohexylcarbodiimide / dimethylformamide / 1 h / 0 °C
2: 90 percent / pyridine / 5 h / 80 °C
3: 49 percent / imidazole / dimethylformamide / Ambient temperature
View Scheme
参考文献
Igolen, Jean; Morin, Christophe
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4802 - 4804
反应条件
1H-imidazole in N,N-dimethyl-formamide
Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Koga; Wilk; Moore; Scremin; Zhou; Beaucage
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1520 - 1530
反应条件
1: pyridine; chloro-trimethyl-silane
2: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere
View Scheme
参考文献
Lucas; Elchinger; Faugeras; Zerrouki
Nucleosides, Nucleotides and Nucleic Acids, 2010 , vol. 29, # 3 p. 168 - 177
