2-氨基-5-甲基-3-噻吩羧酰胺合成路线 （共 3 条）
反应条件
1: With sulfuric acid
T=20°C; 20 h;
2: With sodium hydroxide in water
T=0°C; pH=7;
参考文献
JANSSEN PHARMACEUTICA N.V.; ADDEX PHARMACEUTICALS S.A.
Patent: WO2006/30031 A1, 2006 ;
Location in patent: Page/Page column 57 ;
WO 2006/030031 A1
反应条件
octasulfur; triethylamine in DMF (N,N-dimethyl-formamide); ethanol
T=20 - 70°C; 1.5 h;
参考文献
Nihon Nohyaku Co., Ltd.
Patent: EP1544202 A1, 2005 ;
Location in patent: Page/Page column 51 ;
反应条件
sulfur in ethanol
T=60°C; 1.5 h;
参考文献
AMBIT BIOSCIENCES CORPORATION; HADD, Michael, J.; HOLLADAY, Mark, W.; SETTI, Eduardo
Patent: WO2012/30894 A1, 2012 ;
Location in patent: Page/Page column 99 ;
WO 2012/030894 A1
