反应条件
1.1: N,N-dimethyl-formamide / 90 °C
2.1: potassium permanganate / water / 2 h / Reflux
2.2: pH 1 - 2
3.1: triethylamine / tetrahydrofuran / -5 °C / Inert atmosphere
3.2: pH 1 - 2
4.1: water; sodium tetrahydroborate / tetrahydrofuran / -5 - 20 °C / Inert atmosphere
4.2: pH 1 - 2
View Scheme
参考文献
PFIZER INC.; BUNNAGE, Mark, Edward; COOK, Andrew, Simon; CUI, Jingrong, Jean; DACK, Kevin, Neil; DEAL, Judith, Gail; GU, Danlin; HE, Mingying; JOHNSON, Patrick, Stephen; JOHNSON, Ted, William; LE, Phuong, Thi, Quy; PALMER, Cynthia, Louise; SHEN, Hong
Patent: WO2011/138751 A2, 2011 ;