4-氨基苯基吗啉-4-基甲酮合成路线 （共 7 条）
参考文献
CGI PHARMACEUTICALS, INC.
Patent: WO2008/33834 A1, 2008 ;
Location in patent: Page/Page column 67-68 ;
反应条件
1: With hydrogenchloride in 1,4-dioxane T=20°C; 3 h; 2: With sodium hydrogencarbonate in water pH=8;
参考文献
MEDICAL RESEARCH COUNCIL TECHNOLOGY; MCIVER, Edward, Giles; HOUGH, Joane
Patent: WO2010/100431 A1, 2010 ;
Location in patent: Page/Page column 52 ;
WO 2010/100431 A1
反应条件
potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether in toluene T=105°C; P=3000.3 Torr; 12 h;
参考文献
Dang, Tuan T.; Zhu, Yinghuai; Ngiam, Joyce S. Y.; Ghosh, Subhash C.; Chen, Anqi; Seayad, Abdul M.
ACS Catalysis, 2013 , vol. 3, # 6 p. 1406 - 1410
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
Chen, Huifen; Chan, Bryan K.; Drummond, Jason; Estrada, Anthony A.; Gunzner-Toste, Janet; Liu, Xingrong; Liu, Yichin; Moffat, John; Shore, Daniel; Sweeney, Zachary K.; Tran, Thuy; Wang, Shumei; Zhao, Guiling; Zhu, Haitao; Burdick, Daniel J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5536 - 5545
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C 2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C View Scheme
参考文献
Sun, Ranfeng; Wang, Ziwen; Li, Yongqiang; Xiong, Lixia; Liu, Yuxiu; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2013 , vol. 61, # 3 p. 517 - 522
反应条件
1: thionyl chloride / 3 h / |Reflux 2: triethylamine / dichloromethane / 0 - 20 °C 3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C View Scheme
参考文献
Sun, Ranfeng; Wang, Ziwen; Li, Yongqiang; Xiong, Lixia; Liu, Yuxiu; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2013 , vol. 61, # 3 p. 517 - 522
反应条件
(i) NaNO2, aq. HCl, (ii) /BRN= 605257/; Multistep reaction;
参考文献
Voronin,V.G. et al.
Journal of Organic Chemistry USSR (English Translation), 1979 , vol. 15, p. 56 - 60
Zhurnal Organicheskoi Khimii, 1979 , vol. 15, p. 63 - 68
Full Text Show Details
Kravchenko,A.I. et al.
Pharmaceutical Chemistry Journal, 1976 , vol. 10, # 11 p. 1497 - 1500
Khimiko-Farmatsevticheskii Zhurnal, 1976 , vol. 10, # 11 p. 72 - 75
