2-氧代-3-吲哚羧酸乙酯合成路线 （共 19 条）
反应条件
pyridine in diethyl ether 1) 0 deg C, 1 h, 2) r.t., 5 h;
参考文献
Catarzi, Daniela; Colotta, Vittoria; Varano, Flavia; Cecchi, Lucia; Filacchioni, Guido; Galli, Alessandro; Costagli, Chiara
Archiv der Pharmazie, 1997 , vol. 330, # 12 p. 383 - 386
参考文献
LECTUS THERAPEUTICS LIMITED; KHAN, Nawaz Mohammed; BURCKHARDT, Svenja; CANSFIELD, Julie Elaine; VO, Ngoc-Tri; ARMER, Richard Edward; BOFFEY, Raymond John
Patent: WO2010/1179 A2, 2010 ;
Location in patent: Page/Page column 61; 66 ;
WO 2010/001179 A2
反应条件
tert.-butylhydroperoxide; water; copper dichloride in dichloromethane T=20°C; P=760.051 Torr; 24 h;
参考文献
Wu, Ji-Cheng; Song, Ren-Jie; Wang, Zhi-Qiang; Huang, Xiao-Cheng; Xie, Ye-Xiang; Li, Jin-Heng
Angewandte Chemie - International Edition, 2012 , vol. 51, # 14 p. 3453 - 3457
反应条件
in neat (no solvent) T=180 - 185°C; 0.5 h;
参考文献
Rawal, Viresh H.; Cava, Michael P.
Tetrahedron Letters, 1985 , vol. 26, # 50 p. 6141 - 6142
反应条件
in tetrahydrofuran; diethyl ether; ethanol T=-60 - 20°C;
参考文献
Kozikowski, Alan P.; Gaisina, Irina N.; Yuan, Hongbin; Petukhov, Pavel A.; Blond, Sylvie Y.; Fedolak, Allison; Caldarone, Barbara; McGonigle, Paul
Journal of the American Chemical Society, 2007 , vol. 129, # 26 p. 8328 - 8332
反应条件
1: diethyl ether; tetrahydrofuran / 0 - 20 °C 2: diethyl ether; tetrahydrofuran; ethanol / -60 - 20 °C View Scheme
参考文献
Wang, Hui; Zhu, Ting-Shun; Xu, Ming-Hua
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 46 p. 9158 - 9164,7
Title/Abstract Full Text Show Details
Wang, Hui; Zhu, Ting-Shun; Xu, Ming-Hua
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 46 p. 9158 - 9164
参考文献
Oddo; Albanese
Gazzetta Chimica Italiana, 1927 , vol. 57, p. 827,830
参考文献
Majima; Shigematsu
Chemische Berichte, 1924 , vol. 57, p. 1452
反应条件
pyridine; sodium ethanolate
参考文献
Elks et al.
Journal of the Chemical Society, 1944 , p. 629,631
反应条件
acetic acid in ethanol T=140°C; 0.05 h; microwave irradiation;
参考文献
Colotta, Vittoria; Capelli, Francesca; Lenzi, Ombretta; Catarzi, Daniela; Varano, Flavia; Poli, Daniela; Vincenzi, Fabrizio; Varani, Katia; Borea, Pier Andrea; Dal Ben, Diego; Volpini, Rosaria; Cristalli, Gloria; Filacchioni, Guido
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 401 - 410
