反式-4-氨基环己醇盐酸盐合成路线 （共 20 条）
反应条件
potassium carbonate in acetonitrile T=20 - 30°C; 12 h; Inert atmosphere;
参考文献
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co. Ltd.
Patent: EP2481739 A1, 2012 ;
Location in patent: Page/Page column 40 ;
反应条件
1: With water; sodium hydrogencarbonate in ethyl acetate 2: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 3: With water; sodium hydroxide Cooling with ice;
参考文献
CORTEX PHARMACEUTICALS, INC.
Patent: WO2008/143963 A1, 2008 ;
Location in patent: Example 51 ;
反应条件
1: 100 percent / aq. Na2CO3 / tetrahydrofuran / 0.5 h / Ambient temperature 2: 80 percent / LAH / tetrahydrofuran / Heating View Scheme
参考文献
Venuti, Michael C.; Jones, Gordon H.; Alvarez, Robert; Bruno, John J.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 303 - 318
反应条件
1: KOH; Et3N / acetonitrile 2: 80 percent / PPh3; DEAD / tetrahydrofuran / 25 °C View Scheme
参考文献
Cheng, Jie; Trudell, Mark L.
Organic Letters, 2001 , vol. 3, # 9 p. 1371 - 1373
反应条件
sodium carbonate in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Venuti, Michael C.; Jones, Gordon H.; Alvarez, Robert; Bruno, John J.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 303 - 318
反应条件
potassium carbonate in water T=20°C; 1 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MARKWALDER, Jay A.; FINK, Brian E.; GAVAI, Ashvinikumar V.; HE, Liqi; KIM, Soong-Hoon; SEITZ, Steven P.
Patent: WO2011/123493 A1, 2011 ;
Location in patent: Page/Page column 60 ;
WO 2011/123493 A1
反应条件
triethylamine in tetrahydrofuran; ethyl acetate
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
in tetrahydrofuran; water
参考文献
Merck and Co., Inc.
Patent: US5574044 A1, 1996 ;
US 5574044 A
参考文献
WO2007/62334 A2, ;
Page/Page column 11 ;
反应条件
1: trans-4-amino-cyclohexanol hydrochloride With sodium hydroxide in 1,4-dioxane; water T=0°C; 0.25 h; 2: di-tert-butyl dicarbonate in 1,4-dioxane; water T=20°C; 14 h;
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Brown, Gregory D.; Duncia, John V.; Gardner, Daniel S.; Yang, Michael G.
Patent: US2005/54626 A1, 2005 ;
Location in patent: Page/Page column 47 ;
US 20050054626 A1
