2-(4-甲氧基苯基氨基)乙酸乙酯合成路线 （共 20 条）
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=0 - 25°C; 2.5 h;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2007/4028 A2, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
1: (αS,βR)-α-amino-β-hydroxybutyric acid With hydrogenchloride; sodium nitrite 2: DL-4-methoxyphenylglycine ethyl ester With chloroformic acid ethyl ester; triethylamine
参考文献
Zhou, Guo-Bin; Guan, Yue-Qing; Tang, He; Zhao, Yan-Bin; Yang, Li-Rong
Research on Chemical Intermediates, 2012 , vol. 38, # 1 p. 251 - 259
反应条件
1: With water; sodium hydroxide in tetrahydrofuran; ethanol T=40°C; 3 h; 2: With phosphoric acid in tetrahydrofuran; ethanol; water pH=3;
参考文献
UNIVERSITY OF LEICESTER; ANDREW, Peter William; LONNEN, Rana; DAMASO, Mafalda Pires; FRICKEL, Fritz-Frieder; HIRST, Simon Christopher; DAVIES, Mark William; HAMZA, Daniel
Patent: WO2013/83975 A2, 2013 ;
Location in patent: Page/Page column 44 ;
反应条件
hydrazine hydrate in ethanol; water 5 h; Heating;
参考文献
Journal of the Indian Chemical Society, , vol. 61, # 1 p. 74 - 76
反应条件
1: DL-4-methoxyphenylglycine ethyl ester With 2,3-dicyano-5,6-dichloro-p-benzoquinone in N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: 2-Methyl quinoline in N,N-dimethyl-formamide T=70°C; 24 h; Inert atmosphere; diastereoselective reaction;
参考文献
Zhang, Yong-Gang; Xu, Jing-Kun; Li, Xi-Ming; Tian, Shi-Kai
European Journal of Organic Chemistry, 2013 , # 18 p. 3648 - 3652
反应条件
copper (II) acetate monohydrate; 2,3-dicyano-5,6-dichloro-p-benzoquinone in chloroform T=0 - 20°C;
参考文献
Xie, Jin; Huang, Zhi-Zhen
Angewandte Chemie - International Edition, 2010 , vol. 49, # 52 p. 10181 - 10185
反应条件
sodium acetate in ethanol
T=85 - 90°C;
参考文献
Rohlmann, Renate; Stopka, Tobias; Richter, Heinrich; Garcia Mancheno, Olga
Journal of Organic Chemistry, 2013 , vol. 78, # 12 p. 6050 - 6064
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide
0.5 h;
2: With sodium iodide dihydrate in N,N-dimethyl-formamide
Inert atmosphere;
参考文献
Huang, Wenhua; Sha, Wen-Bin
Journal of Chemical Research, 2013 , vol. 37, # 8 p. 460 - 463
反应条件
Fe(tpfc)(OEt2)2 in diethyl ether
T=20°C; 0.0333333 h;
参考文献
Aviv, Iris; Gross, Zeev
Chemistry - A European Journal, 2008 , vol. 14, # 13 p. 3995 - 4005
反应条件
isopropyl alcohol; [Ru(CO)2(Ph4C4CO)]2 in water; toluene
T=110°C; 1 h;
参考文献
Samec, Joseph S.M.; Mony, Laetitia; Baeckvall, Jan-E.
Canadian Journal of Chemistry, 2005 , vol. 83, # 6-7 p. 909 - 916
