反应条件
1: 97 percent / K2CO3 / acetone / 16 h
2: 78 percent / 2-methyl-2-butene, aq. NaClO2, NaH2PO4 / dioxane / 6.5 h
3: SOCl2 / 1,2-dichloro-ethane / 2 h / 75 °C
View Scheme
参考文献
Showalter, H. D. Hollis; Sercel, Anthony D.; Leja, Boguslawa M.; Wolfangel, Craig D.; Ambroso, Linda A.; Elliott, William L.; Fry, David W.; Kraker, Alan J.; Howard, Curtis T.; Lu, Gina H.; Moore, Charles W.; Nelson, James M.; Roberts, Bill J.; Vincent, Patrick W.; Denny, William A.; Thompson, Andrew M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 413 - 426