5-(羟基甲基)吡啶甲酸乙酯合成路线 （共 14 条）
反应条件
sulfuric acid; triethylamine; calcium chloride
1.) EtOH, 2.) reflux, 4 h; Yield given. Multistep reaction;
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
sodium tetrahydroborate; sulfuric acid
1) 1 h 0 deg C; 34 h, room temperature, 2) 4 h, reflux; Yield given. Multistep reaction;
参考文献
Barth, Hubert; Burger, Guenther; Doepp, Heinrike; Kobayashi, Makoto; Musso, Hans
Liebigs Annalen der Chemie, 1981 , # 12 p. 2164 - 2179
反应条件
pyridine; chromium(VI) oxide in dichloromethane
4 h; Ambient temperature;
参考文献
Dawson, Marcia I.; Chan, Rebecca; Hobbs, Peter D.; Chao, Wan-ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1282 - 1293
反应条件
thionyl chloride in ethanol
3 h; Heating;
参考文献
Barth, Hubert; Burger, Guenther; Doepp, Heinrike; Kobayashi, Makoto; Musso, Hans
Liebigs Annalen der Chemie, 1981 , # 12 p. 2164 - 2179
