1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-3-羧酸合成路线 (共 4 条)
反应条件
potassium phosphate; copper(l) iodide; N-methyl-2-(methylamino)ethylamine in N,N-dimethyl-formamide
T=90°C; Ullmann Condensation; 20 h; Inert atmosphereSealed tube;
参考文献
ZENTIVA, K.S.; HEJTMANKOVA, Ludmila; JIRMAN, Josef
Patent: WO2014/75648 A1, 2014 ;
Location in patent: Page/Page column 13 ;
反应条件
ammonium hydroxide; CuI; potassium carbonate in dimethyl sulfoxide; ethyl acetate
参考文献
Zhou, Jiacheng; Oh, Lynette M.; Ma, Philip; Li, Hui-Yin; Confalone, Pasquale
Patent: US2003/181466 A1, 2003 ;
反应条件
1: triethylamine / ethyl acetate / 2 h / 0 °C / |Inert atmosphere; |Cooling with ice; |Reflux
2: N-methyl-2-(methylamino)ethylamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 20 h / 90 °C / |Inert atmosphere; |Sealed tube
View Scheme
参考文献
ZENTIVA, K.S.; HEJTMANKOVA, Ludmila; JIRMAN, Josef
Patent: WO2014/75648 A1, 2014 ;
反应条件
1: triethylamine / ethyl acetate / 2 h / 0 °C / |Inert atmosphere; |Cooling with ice; |Reflux
2: N-methyl-2-(methylamino)ethylamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 20 h / 90 °C / |Inert atmosphere; |Sealed tube
View Scheme
参考文献
ZENTIVA, K.S.; HEJTMANKOVA, Ludmila; JIRMAN, Josef
Patent: WO2014/75648 A1, 2014 ;