2-(羟基苯基甲基)苯并咪唑合成路线 （共 8 条）
反应条件
1: 1-(1-pyrrolidinomethyl)benzimidazole With n-butyllithium in tetrahydrofuran; hexane
T=-80°C; 0.25 h;
2: benzaldehyde in tetrahydrofuran; hexane
T=-80 - -20°C; 3 h;
3: With ammonium chloride in tetrahydrofuran; hexane
参考文献
BIOPROJET; BERREBI-BERTRAND, Isabelle; BILLOT, Xavier; CALMELS, Thierry; CAPET, Marc; DANVY, Denis; KRIEF, Stephane; LABEEUW, Olivier; LECOMTE, Jeanne-Marie; LEVOIN, Nicolas; LIGNEAU, Xavier; ROBERT, Philippe; SCHWARTZ, Jean-Charles
Patent: WO2012/41860 A1, 2012 ;
Location in patent: Page/Page column 63 ;
反应条件
hydrogenchloride
Condensation; 3 h; Heating;
参考文献
Ramaiah; Grossert; Hooper; Dubey; Ramanatham
Journal of the Indian Chemical Society, 1999 , vol. 76, # 3 p. 140 - 144
反应条件
1: tetrahydrofuran / 0.08 h / 20 °C
2: 1.) LDA / 1.) THF, -20 deg C, 60 min, 2.) from -78 deg C to 20 deg C, 8 h
View Scheme
参考文献
Katritzky, Alan R.; Akutagawa, Kunihiko
Journal of Organic Chemistry, 1989 , vol. 54, # 12 p. 2949 - 2952
反应条件
in tetrahydrofuran
T=-20°C; 1 h;
参考文献
Ooi, Hong Chin; Suschitzky, Hans
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 12 p. 2871 - 2876
反应条件
lithium diisopropyl amide
1.) THF, -20 deg C, 60 min, 2.) from -78 deg C to 20 deg C, 8 h; Yield given. Multistep reaction;
参考文献
Katritzky, Alan R.; Akutagawa, Kunihiko
Journal of Organic Chemistry, 1989 , vol. 54, # 12 p. 2949 - 2952
参考文献
Georgescu
Chemische Berichte, 1892 , vol. 25, p. 952
反应条件
KMnO4/alumina
T=20°C; 0.116667 h;
参考文献
Dubey; Kumar, C. Ravi; Babu, Balaji
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 12 p. 3128 - 3130
参考文献
Bistrzycki; Przeworski
Chemische Berichte, 1912 , vol. 45, p. 3495
