4-羟基吡啶-2,6-二甲酸合成路线 （共 47 条）
反应条件
ammonium hydroxide in water T=100°C; 5 h;
参考文献
Gan, Xin-Min; Paine, Robert T.; Duesler, Eileen N.; Noeth, Heinrich
Dalton Transactions, 2003 , # 1 p. 153 - 159
反应条件
1: With hydrogenchloride 2: With ammonia
参考文献
Gan, Xin-Min; Paine, Robert T.; Duesler, Eileen N.; Noeth, Heinrich
Dalton Transactions, 2003 , # 1 p. 153 - 159
反应条件
potassium hydroxide T=150°C;
参考文献
Kuczinski
Acta Poloniae Pharmaceutica, 1955 , vol. 12, p. 105,109
Chem.Abstr., 1956 , p. 3427
反应条件
sulfuric acid Diazotization.Behandeln der Reaktionsloesung mit heissem H2O;
参考文献
Kuczinski
Acta Poloniae Pharmaceutica, 1955 , vol. 12, p. 105,109
Chem.Abstr., 1956 , p. 3427
反应条件
potassium hydroxide; potassium permanganate
参考文献
Ochiai; Fujimoto
Pharmaceutical Bulletin, 1954 , vol. 2, p. 131,136
反应条件
1: aqueous KMnO4 2: aqueous NaOH 3: aqueous H2SO4 / Diazotization.Behandeln der Reaktionsloesung mit heissem H2O View Scheme
参考文献
Kuczinski
Acta Poloniae Pharmaceutica, 1955 , vol. 12, p. 105,109
Chem.Abstr., 1956 , p. 3427
反应条件
1: aqueous NaOH 2: aqueous H2SO4 / Diazotization.Behandeln der Reaktionsloesung mit heissem H2O View Scheme
参考文献
Kuczinski
Acta Poloniae Pharmaceutica, 1955 , vol. 12, p. 105,109
Chem.Abstr., 1956 , p. 3427
反应条件
1: sodium acetate; acetic acid / 200 °C / Erhitzen des Reaktionsprodukts mit wss.Salzsaeure 2: KMnO4; aqueous KOH View Scheme
参考文献
Ochiai; Fujimoto
Pharmaceutical Bulletin, 1954 , vol. 2, p. 131,136
反应条件
1: chelidamic acid With trichlorophosphate Heating / reflux; 2: ethanol With triethylamine in tetrahydrofuran T=0 - 20°C; 0.5 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/82487 A2, 2008 ;
Location in patent: Page/Page column 155 ;
WO 2008/082487 A2
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / Heating 2: pyridine View Scheme
参考文献
Chaubet; Nguyen Van Duong; Courtieu; Gaudemer; Gref; Crumbliss
Canadian Journal of Chemistry, 1991 , vol. 69, # 7 p. 1107 - 1116
