1: 1,3-dihydroxy-4-methylbenzene With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 0.25 h; 2: chloromethyl methyl ether in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; 1 h;
参考文献
AUTIFONY THERAPEUTICS LIMITED; ALVARO, Giuseppe; DAMBRUOSO, Paolo; MARASCO, Agostino; TOMMASI, Simona; DECOR, Anne; LARGE, Charles
Patent: WO2012/76877 A1, 2012 ;
Location in patent: Page/Page column 142 ;
WO 2012/076877 A1
diethyl ether; zinc(II) chloride
Durch Erhitzen des Reaktionsprodukts mit wss. H2SO4;
参考文献
Bhandari et al.
Journal of Scientific and Industrial Research, 1949 , vol. 8 B, p. 217,218
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Whalley
Journal of the Chemical Society, 1957 , p. 1833,1834