[1,3]二氧杂环戊并[4,5-g]苯并吡喃-6-酮合成路线 （共 26 条）
反应条件
1: With aluminum tri-bromide in ethanethiol T=0 - 20°C; 2: With hydrogenchloride in water T=0 - 20°C; Product distribution / selectivity;
参考文献
Kureha Chemical Industry Co., Ltd.
Patent: EP1357118 A1, 2003 ;
Location in patent: Page/Page column 11-12 ;
反应条件
sodium acetate in N,N-dimethyl-formamide
T=170°C; 5 h;
参考文献
Kureha Chemical Industry Co., Ltd.
Patent: EP1357118 A1, 2003 ;
Location in patent: Page/Page column 11 ;
反应条件
zinc(II) chloride
T=100°C; 1 h; neat (no solvent); regioselective reaction;
参考文献
Leao, Raquel A. C.; Def.demoraes, Paula; Pedro, Marcella C. B. C.; Costa, Paulo R. R.
Synthesis, 2011 , # 22 art. no. M70011SS, p. 3692 - 3696
反应条件
anhydrous iron chloride; silver trifluoromethanesulfonate; trifluoroacetic acid in 1,2-dichloro-ethane
T=30°C; 15 h;
参考文献
Kutubi, Shahajahan; Hashimoto, Takuya; Kitamura, Tsugio
Synthesis, 2011 , # 8 art. no. F16111SS, p. 1283 - 1289
反应条件
ytterbium(III) triflate in nitromethane
T=100°C; 1.5 h;
参考文献
Fillion, Eric; Dumas, Aaron M.; Kuropatwa, Bryan A.; Malhotra, Neil R.; Sitler, Tamsyn C.
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 409 - 412
反应条件
in toluene
T=60°C; Wittig reaction;
参考文献
Gagey, Nathalie; Neveu, Pierre; Benbrahim, Chouaha; Goetz, Bernard; Aujard, Isabelle; Baudin, Jean-Bernard; Jullien, Ludovic
Journal of the American Chemical Society, 2007 , vol. 129, # 32 p. 9986 - 9998
反应条件
potassium carbonate in dimethyl sulfoxide
3 h; Heating;
参考文献
Tal, Beni; Robeson, David J.
Phytochemistry (Elsevier), 1986 , vol. 25, # l p. 77 - 80
反应条件
N,N-diethylaniline
T=220°C; Wittig reaction; 4 h;
参考文献
Riveiro, Maria E.; Maes, Dominick; Vazquez, Ramiro; Vermeulen, Monica; Mangelinckx, Sven; Jacobs, Jan; Debenedetti, Silvia; Shayo, Carina; De Kimpe, Norbert; Davio, Carlos
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6547 - 6559
反应条件
1: 97 percent / K2CO3 / acetone / 12 h / Heating
2: 93 percent / dimethylformamide / 12 h / 190 °C
3: 96 percent / potassium tert-butoxide / tetrahydrofuran / 12 h / 20 °C
4: 93 percent / triethylamine / CH2Cl2 / 3 h / 20 °C
5: 83 percent / Grubbs' second generation catalyst / CH2Cl2 / 24 h / Heating
View Scheme
参考文献
Nguyen Van, Tuyen; Debenedetti, Silvia; De Kimpe, Norbert
Tetrahedron Letters, 2003 , vol. 44, # 22 p. 4199 - 4201
反应条件
Grubb's 2nd generation catalyst in dichloromethane
ring closing metathesis; 24 h; Heating;
参考文献
Nguyen Van, Tuyen; Debenedetti, Silvia; De Kimpe, Norbert
Tetrahedron Letters, 2003 , vol. 44, # 22 p. 4199 - 4201
