2-氯-3-硝基-咪唑并[1,2-a]吡啶合成路线 （共 8 条）
反应条件
sulfuric acid; nitric acid
T=-5 - 20°C; 3.5 h;
参考文献
Bazin, Marc-Antoine; Marhadour, Sophie; Tonnerre, Alain; Marchand, Pascal
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5378 - 5382
反应条件
1: trichlorophosphate / toluene / 16 h / |Reflux
2: sulfuric acid; nitric acid / 3.5 h / -5 - 20 °C
View Scheme
参考文献
Bazin, Marc-Antoine; Marhadour, Sophie; Tonnerre, Alain; Marchand, Pascal
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5378 - 5382
反应条件
1.1: triethylamine / water / 0.17 h / 20 °C
1.2: 5 h / 90 °C
2.1: trichlorophosphate / toluene / 16 h / |Reflux
3.1: sulfuric acid; nitric acid / 3.5 h / -5 - 20 °C
View Scheme
参考文献
Bazin, Marc-Antoine; Marhadour, Sophie; Tonnerre, Alain; Marchand, Pascal
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5378 - 5382
反应条件
sodium carbonate
2.5 h; Heating;
参考文献
Newton, Christopher G.; Ollis, W. David; Wright, Derek E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 69 - 73
反应条件
sodium hydroxide in ethanol; water
1.) reflux, 30 min, 2.) 0 deg C, 30 min;
参考文献
Newton, Christopher G.; Ollis, W. David; Wright, Derek E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 69 - 73
反应条件
sodium carbonate
2.5 h; Heating;
参考文献
Newton, Christopher G.; Ollis, W. David; Wright, Derek E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 69 - 73
反应条件
in N,N-dimethyl-formamide
T=125°C; 8 h;
参考文献
Winkelmann; Raether; Hartung; Wagner
Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 1 p. 82 - 89
反应条件
in 1-methyl-pyrrolidin-2-one
T=170°C; 96 h; Sealed tube;
参考文献
Bazin, Marc-Antoine; Marhadour, Sophie; Tonnerre, Alain; Marchand, Pascal
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5378 - 5382
