3-甲基异恶唑-5-甲酸合成路线 （共 25 条）
反应条件
oxalyl dichloride in toluene 12 h; Heating;
参考文献
Pae, Ae Nim; Kim, Hye Yeon; Joo, Hyun Jin; Kim, Bo Hyung; Cho, Yong Seo; Choi, Kyung Il; Choi, Jung Hoon; Koh, Hun Yeong
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 18 p. 2679 - 2684
参考文献
Cusmano
Gazzetta Chimica Italiana, 1940 , vol. 70, p. 240,244
反应条件
thionyl chloride T=50°C;
参考文献
SHIONOGI and CO., LTD.
Patent: EP1894919 A1, 2008 ;
Location in patent: Page/Page column 23 ;
EP 1894919 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2 h; Inert atmosphere;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
参考文献
Pfizer Inc.
Patent: US4342771 A1, 1982 ;
