N-苯甲酰-2'-脱氧胞苷合成路线 （共 36 条）
反应条件
1: pyridine
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH2Cl2
3: tetrabutylammonium fluoride / tetrahydrofuran
View Scheme
参考文献
Diaz-Rodriguez, Alba; Fernandez, Susana; Sanghvi, Yogesh S.; Ferrero, Miguel; Gotor, Vicente
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 581 - 587
反应条件
1: 1.) dimethylaminopyridine, Et3N, 2.) pyridine / 1) pyridine
2: potassium phthalimide / dimethylformamide
3: 1.) LiN3, 2.) aq. HOAc
View Scheme
参考文献
Wojczcwski; Faulstich; Engels
Nucleosides and Nucleotides, 1997 , vol. 16, # 5-6 p. 751 - 754
反应条件
ammonia; methylamine in water
T=65°C; 1 h; deprotection reagent; Product distribution;
参考文献
Reddy, M. P.; Hanna, N. B.; Farooqui, Firdous
Tetrahedron Letters, 1994 , vol. 35, # 25 p. 4311 - 4314
反应条件
1H-imidazole in N,N-dimethyl-formamide
T=0°C; 3 h; Inert atmosphere;
参考文献
Lucas; Elchinger; Faugeras; Zerrouki
Nucleosides, Nucleotides and Nucleic Acids, 2010 , vol. 29, # 3 p. 168 - 177
反应条件
1H-imidazole in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Igolen, Jean; Morin, Christophe
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4802 - 4804
反应条件
1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 1.) 22 deg C, 1 h, 2.) r.t., 24 h
2: NaHCO3 / methanol
3: imidazole / dimethylformamide
View Scheme
参考文献
Koga; Wilk; Moore; Scremin; Zhou; Beaucage
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1520 - 1530
