5-氯吲哚-2-羧酸乙酯合成路线 （共 37 条）
参考文献
El-Gendy, Adel A.; Said, Mohamed M.; Ghareb, Nagat; Mostafa, Yasser M.; El-Ashry, El Sayed H.
Archiv der Pharmazie, 2008 , vol. 341, # 5 p. 294 - 300
反应条件
1: 1.) NaNO2, HCl, 2.) KOH 2: H3PO4 View Scheme
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
反应条件
1: acetic acid / ethanol / Reflux 2: polyphosphoric acid / 4 h / 100 °C View Scheme
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
参考文献
Terzioglu, Nalan; Van Rijn, Richard M.; Bakker, Remko A.; De Esch, Iwan J.P.; Leurs, Rob
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5251 - 5256
反应条件
2: polyphosphoric acid View Scheme
参考文献
Rydon; Tweddle
Journal of the Chemical Society, 1955 , p. 3499,3502
反应条件
1: ethanolic KOH 2: copper oxide-chromium oxide; quinoline / 215 °C View Scheme
参考文献
Journal of the Chemical Society, , p. 3499,3502
反应条件
ammonia; calcium chloride in methanol T=80°C; P=1275.13 Torr; 24 h; Inert atmosphere;
参考文献
Bundesmann, Mark W.; Coffey, Steven B.; Wright, Stephen W.
Tetrahedron Letters, 2010 , vol. 51, # 30 p. 3879 - 3882
反应条件
hydrazine hydrate in ethanol Heating;
参考文献
Sinnur, K. H.; Siddappa, S.; Hiremath, Shivayogi P.; Purohit, Muralidhar G.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 716 - 720
反应条件
phosphoric acid; trifluoroacetic anhydride in acetonitrile 5.2 h; Ambient temperature;
参考文献
Murakami; Tani; Suzuki; et al.
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4707 - 4716
反应条件
1.1: sodium hydroxide / ethanol / 3 h / Reflux 1.2: pH 5 / Cooling with ice 2.1: quinoline; copper / 3 h / Neat (no solvent); Reflux 3.1: acetic acid / 20 h / Reflux View Scheme
参考文献
Zhang, Fan; Zhao, Yanfang; Sun, Li; Ding, Lu; Gu, Yucheng; Gong, Ping
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3149 - 3157
