2-(1-哌啶基甲基)苯酚合成路线 （共 10 条）
反应条件
water in various solvent(s) T=99°C; hydrolysis rate constants at pH 8.83 and 10.0; Rate constant;
参考文献
Teitel'baum, A. B.; Kudryavtseva, L. A.; Bel'skii, V. E.; Ivanov, V. E.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 1 p. 72 - 75
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 1 p. 81 - 85
反应条件
toluene-4-sulfonic acid in benzene
Mannich reaction; 1 h; Reflux;
参考文献
Antonov, Liudmil; Deneva, Vera; Simeonov, Svilen; Kurteva, Vanya; Nedeltcheva, Daniela; Wirz, Jakob
Angewandte Chemie - International Edition, 2009 , vol. 48, # 42 p. 7875 - 7878
反应条件
hydrogen bromide in water
T=125°C; 3 h;
参考文献
Mustazza, Carlo; Borioni, Anna; Giudice, Maria Rosaria Del; Gatta, Franco; Ferretti, Rosella; Meneguz, Annarita; Volpe, Maria Teresa; Lorenzini, Paola
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 2 p. 91 - 109
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C;
参考文献
Assimomytis, Nikos; Sariyannis, Yiannis; Stavropoulos, Georgios; Tsoungas, Petros G.; Varvounis, George; Cordopatis, Paul
Synlett, 2009 , # 17 p. 2777 - 2782
反应条件
formic acid
T=110 - 115°C; 2 h;
参考文献
Bonjean; Schunack
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 4 p. 501 - 507
反应条件
sulfur dioxide in acetonitrile
T=0 - 20°C; aminomethylation; 42 h;
参考文献
Heaney, Harry; Papageorgiou, George; Wilkins, Robert F.
Tetrahedron, 1997 , vol. 53, # 39 p. 13361 - 13372
反应条件
sodium hydroxide
T=80°C; pH=12; 1 h;
参考文献
Modica; Zanaletti; Freccero; Mella
Journal of Organic Chemistry, 2001 , vol. 66, # 1 p. 41 - 52
反应条件
in acetonitrile
T=0 - 20°C; aminomethylation; 43 h;
参考文献
Heaney, Harry; Papageorgiou, George; Wilkins, Robert F.
Tetrahedron, 1997 , vol. 53, # 39 p. 13361 - 13372
反应条件
T=50°C; Mannich reaction; P=4500450 Torr; 96 h; regioselective reaction;
参考文献
Matsumoto, Kiyoshi; Joho, Kouta; Mimori, Seisuke; Iida, Hirokazu; Hamana, Hiroshi; Kakehi, Akikazu
Heterocycles, 2008 , vol. 76, # 2 p. 1061 - 1067
反应条件
hydrogenchloride in 1,4-dioxane
1 h; Heating;
参考文献
Komolafe; Femi-Onadeko
Bulletin des Societes Chimiques Belges, 1982 , vol. 91, # 6 p. 569 - 572
